Cellosaurus FTC-133 (CVCL_1219)

Cell line name FTC-133
Synonyms FTC133
Accession CVCL_1219
Resource Identification Initiative To cite this cell line use: FTC-133 (RRID:CVCL_1219)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: PTEN p.Arg130Ter (PubMed=23162534).
Sequence variation: TP53 p.Arg273His (PubMed=23162534).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: FTC-113; In Cosmic 1889011.
Disease Thyroid gland follicular carcinoma (NCIt: C8054)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2446 ! FTC-236
CVCL_2447 ! FTC-238
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=18713817; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D13S31711
D16S53911
D18S5111,12
D19S43312,13
D21S1132.2
D2S133820
D3S135815
D5S81812
D7S8209,10 (Cosmic-CLP; ECACC; PubMed=18713817)
10 (PubMed=25877200)
D8S117910
FGA21
Penta D12
Penta E13
TH019.3 (Cosmic-CLP; ECACC)
6.1,9.3 (PubMed=25877200)
TPOX9
vWA15,18
Publications

PubMed=1726925
Gerber H., Peter H.J., Asmis L., Studer H.
Thyroid cell lines in research on goitrogenesis.
Thyroidology 3:115-118(1991)

PubMed=1384245; DOI=10.1007/BF02067383
Demeure M.J., Damsky C.H., Elfman F., Goretzki P.E., Wong M.G., Clark O.H.
Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases.
World J. Surg. 16:770-776(1992)

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026
van Staveren W.C.G., Solis D.W., Delys L., Duprez L., Andry G., Franc B., Thomas G., Libert F., Dumont J.E., Detours V., Maenhaut C.
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer Res. 67:8113-8120(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A., Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23162534; DOI=10.3389/fendo.2012.00133
Saiselet M., Floor S., Tarabichi M., Dom G., Hebrant A., van Staveren W.C.G., Maenhaut C.
Thyroid cancer cell lines: an overview.
Front. Endocrinol. 3:133-133(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ECACC; 94060901
ICLC; HTL97015
Cell line databases/resources CLDB; cl1398
CLDB; cl1399
CCLE; FTC133_THYROID
Cosmic-CLP; 906864
GDSC; 906864
LINCS_LDP; LCL-1677
Ontologies BTO; BTO:0001889
CLO; CLO_0003402
Biological sample resources BioSample; SAMN03471027
Chemistry resources ChEMBL-Cells; CHEMBL3308732
ChEMBL-Targets; CHEMBL1075445
Gene expression databases GEO; GSM827308
GEO; GSM887012
GEO; GSM888081
GEO; GSM1669794
Polymorphism and mutation databases Cosmic; 906864
Cosmic; 928831
Cosmic; 1239976
Cosmic; 1280044
Cosmic; 1507371
Cosmic; 1533556
Cosmic; 1536124
Cosmic; 1889011
Cosmic; 2054103
Cosmic; 2319848