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Cellosaurus FTC-133 (CVCL_1219)

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Cell line name FTC-133
Synonyms FTC133
Accession CVCL_1219
Resource Identification Initiative To cite this cell line use: FTC-133 (RRID:CVCL_1219)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: TCGA-110-CL cell line panel.
Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Mitochondrial genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Anecdotal: Have been flown in space on Shenzhou-8 and on the ISS to study growth in microgravity (PubMed=23866977; PubMed=24196587; PubMed=25930030).
Misspelling: FTC-113; In Cosmic 1889011.
Misspelling: CFT-133; In PubMed=1384245 in the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.
Sequence variations Mutation; HGNC; 27310; FLCN; Simple; p.His429Thrfs*39 (c.1285delC); ClinVar=VCV000003364; Zygosity=Homozygous (PubMed=30737244).
Mutation; HGNC; 7329; MSH6; Simple; p.Lys1045fs (c.3135delG); Zygosity=Homozygous (PubMed=30737244).
Mutation; HGNC; 7765; NF1; Simple; p.Cys167Ter (c.501T>A); ClinVar=VCV001048706; Zygosity=Homozygous (PubMed=30737244).
Mutation; HGNC; 9588; PTEN; Simple; p.Arg130Ter (c.388C>T); ClinVar=VCV000007819; Zygosity=Homozygous (PubMed=23162534; PubMed=23833040; PubMed=30737244).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Homozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=14522906; PubMed=23162534; PubMed=30737244).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.18
East Asian, North4.32
East Asian, South0
South Asian0
European, North56.94
European, South36.26
Disease Thyroid gland follicular carcinoma (NCIt: C8054)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2446 ! FTC-236
CVCL_2447 ! FTC-238
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=18713817; PubMed=25877200; PubMed=30737244

CSF1PO10 (Cosmic-CLP; ECACC; PubMed=25877200)
10,11 (PubMed=30737244)
D5S81811,12 (PubMed=30737244)
12 (Cosmic-CLP; ECACC; PubMed=18713817; PubMed=25877200)
D7S8209,10 (Cosmic-CLP; ECACC; PubMed=18713817; PubMed=30737244)
10 (PubMed=25877200)
Penta D12
Penta E13
TH016.1,9.3 (PubMed=25877200)
9.3 (Cosmic-CLP; ECACC; PubMed=30737244)

Run an STR similarity search on this cell line

Demeure M.J., Hughes-Fulford M., Goretzki P.E., Duh Q.-Y., Clark O.H.
Actin architecture of cultured human thyroid cancer cells: predictor of differentiation?
Surgery 108:986-992(1990)

Gerber H., Peter H.-J., Asmis L., Studer H.
Thyroid cell lines in research on goitrogenesis.
Thyroidology 3:115-118(1991)

PubMed=1384245; DOI=10.1007/BF02067383
Demeure M.J., Damsky C.H., Elfman F., Goretzki P.E., Wong M.G., Clark O.H.
Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases.
World J. Surg. 16:770-776(1992)

Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026
van Staveren W.C.G., Solis D.W., Delys L., Duprez L., Andry G., Franc B., Thomas G., Libert F., Dumont J.E., Detours V., Maenhaut C.
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Cancer Res. 67:8113-8120(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A., Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23162534; DOI=10.3389/fendo.2012.00133
Saiselet M., Floor S., Tarabichi M., Dom G., Hebrant A., van Staveren W.C.G., Maenhaut C.
Thyroid cancer cell lines: an overview.
Front. Endocrinol. 3:133.1-133.9(2012)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=23866977; DOI=10.1016/j.biomaterials.2013.06.054
Pietsch J., Ma X., Wehland M., Aleshcheva G., Schwarzwalder A., Segerer J., Birlem M., Horn A., Bauer J., Infanger M., Grimm D.
Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission.
Biomaterials 34:7694-7705(2013)

PubMed=24196587; DOI=10.1096/fj.13-243287
Ma X., Pietsch J., Wehland M., Schulz H., Saar K., Hubner N., Bauer J., Braun M., Schwarzwalder A., Segerer J., Birlem M., Horn A., Hemmersbach R., Wasser K., Grosse J., Infanger M., Grimm D.
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
FASEB J. 28:813-835(2014)

PubMed=25675381; DOI=10.1210/jc.2014-2764
von Roemeling C.A., Marlow L.A., Pinkerton A.B., Crist A., Miller J., Tun H.W., Smallridge R.C., Copland J.A.
Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.
J. Clin. Endocrinol. Metab. 100:E697-E709(2015)

PubMed=25930030; DOI=10.1002/pmic.201500067
Riwaldt S., Pietsch J., Sickmann A., Bauer J., Braun M., Segerer J., Schwarzwalder A., Aleshcheva G., Corydon T.J., Infanger M., Grimm D.
Identification of proteins involved in inhibition of spheroid formation under microgravity.
Proteomics 15:2945-2952(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29066502; DOI=10.1530/ERC-17-0288
Corver W.E., Demmers J., Oosting J., Sahraeian S., Boot A., Ruano D., Wezel T.V., Morreau H.
ROS-induced near-homozygous genomes in thyroid cancer.
Endocr. Relat. Cancer 25:83-97(2018)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C., Marlow L.A., Smallridge R.C., Copland J.A., Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574-3574(2019)

Cell line collections ECACC; 94060901
ICLC; HTL97015
Cell line databases/resources CLDB; cl1398
CLDB; cl1399
CCRID; 1101HUM-PUMC000687
Cell_Model_Passport; SIDM00213
Cosmic-CLP; 906864
DepMap; ACH-000903
Ontologies BTO; BTO:0001889
CLO; CLO_0003402
Biological sample resources BioSample; SAMN03471027
BioSample; SAMN10987983
Chemistry resources ChEMBL-Cells; CHEMBL3308732
ChEMBL-Targets; CHEMBL1075445
GDSC; 906864
PharmacoDB; FTC133_368_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827308
GEO; GSM887012
GEO; GSM888081
GEO; GSM1669794
Other Wikidata; Q54835217
Polymorphism and mutation databases Cosmic; 906864
Cosmic; 928831
Cosmic; 1239976
Cosmic; 1280044
Cosmic; 1507371
Cosmic; 1533556
Cosmic; 1536124
Cosmic; 1889011
Cosmic; 2054103
Cosmic; 2319848
Cosmic; 2791091
IARC_TP53; 21332
LiGeA; CCLE_543
Progenetix; CVCL_1219
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number33