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Cellosaurus GAK (CVCL_1225)

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Cell line name GAK
Accession CVCL_1225
Resource Identification Initiative To cite this cell line use: GAK (RRID:CVCL_1225)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 72 hours, ~32 hours (lot 02242012), ~55 hours (lot 07202012) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North77.89
East Asian, South22.1
South Asian0
European, North0
European, South0
Disease Vulvar melanoma (NCIt: C40329)
Derived from metastatic site: Inguinal lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 86Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D2S133818,20
D3S135816
D5S81810
D7S82011
D8S117910,11
D13S3179,13
D16S53912
D18S5113
D19S43314,15
D21S1129,30
FGA24
Penta D9,11
Penta E9,10
TH017
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=6431036
Nozawa S., Ohta H., Tsukazaki K., Udagawa Y., Kurihara S., Kano S.
A newly established melanoma cell line (GAK) with 5-S-cysteinyldopa phenotype.
Nihon Sanka Fujinka Gakkai Zasshi 36:883-892(1984)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Tanami H., Imoto I., Hirasawa A., Yuki Y., Sonoda I., Inoue J., Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; IFO50321
JCRB; JCRB0180
JCRB; FDSC0034 - Discontinued
Cell line databases/resources CCLE; GAK_SKIN
Cell_Model_Passport; SIDM00543
CGH-DB; 9290-4
Cosmic-CLP; 910932
DepMap; ACH-002120
GDSC; 910932
LINCS_LDP; LCL-1272
Biological sample resources BioSample; SAMN03472868
Chemistry resources ChEMBL-Cells; CHEMBL3308154
ChEMBL-Targets; CHEMBL2366301
PharmacoDB; GAK_397_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669803
Other Wikidata; Q54835424
Polymorphism and mutation databases Cosmic; 905204
Cosmic; 910932
Cosmic; 1995410
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number25