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Cellosaurus GI-1 (CVCL_1231)

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Cell line name GI-1
Accession CVCL_1231
Resource Identification Initiative To cite this cell line use: GI-1 (RRID:CVCL_1231)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 18 hours (PubMed=1545891).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for CREBBP p.Ser1680del (c.5039_5041delCCT) (CCLE; Cosmic-CLP).
Homozygous for RB1 p.Arg552Ter (c.1654C>T) (CCLE; Cosmic-CLP).
TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).
Homozygous for TP53 p.Cys275Tyr (c.824G>A) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North78.75
East Asian, South20.38
South Asian0.63
European, North0
European, South0.24
Disease Gliosarcoma (NCIt: C3796)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=25877200; RCB

Markers:
AmelogeninX,Y
CSF1PO9
D2S133816,18
D3S135815,18
D5S81811
D7S82011
D8S117910,16
D13S3178
D16S5399,10
D18S5113
D19S43313,14
D21S1129,30
FGA23,24
Penta D11,12
Penta E12,15
TH019
TPOX8,12
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=1545891; DOI=10.1097/00006123-199202000-00013
Iwasaki K., Kikuchi H., Miyatake S.-I., Kondo S., Oda Y.
Establishment of a new cell line derived from a human gliosarcoma.
Neurosurgery 30:228-235(1992)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections RCB; RCB0763
Cell line databases/resources CCLE; GI1_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM00273
Cosmic-CLP; 906871
DepMap; ACH-000756
GDSC; 906871
LINCS_LDP; LCL-1379
Ontologies CLO; CLO_0050634
Biological sample resources BioSample; SAMN03470902
BioSample; SAMN10987799
Chemistry resources ChEMBL-Cells; CHEMBL3308167
ChEMBL-Targets; CHEMBL2366272
PharmacoDB; GI1_404_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887024
GEO; GSM888094
GEO; GSM1669809
Other Wikidata; Q54835802
Polymorphism and mutation databases Cosmic; 687569
Cosmic; 906871
Cosmic; 2367527
IARC_TP53; 21343
LiGeA; CCLE_649
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23