Cellosaurus GI-ME-N (CVCL_1232)

Cell line name GI-ME-N
Synonyms Gi-ME-N; GIMEN; Gimen; Gimen1; Gaslini Institute-ME-Neuroblastoma
Accession CVCL_1232
Resource Identification Initiative To cite this cell line use: GI-ME-N (RRID:CVCL_1232)
Comments Doubling time: ~24 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Neuroblastoma (NCIt: C3270)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D13S31712 (CLS)
8,12 (Cosmic-CLP; DSMZ)
D16S5399,12
D18S5112,17
D21S1131
D3S135814
D5S81812
D7S82010,11
D8S117910,14
FGA19,22
Penta D9,13
Penta E15,20
TH016,7
TPOX11
vWA16,19
Publications

PubMed=3615018
Melodia A., Cornara L., Bertelli R., Canepa M., Gimelli G., Repetto G., Cornaglia-Ferraris P.
New line of human neuroblastoma derived from bone marrow.
Pathologica 78:371-384(1986)

PubMed=3204111; DOI=10.1007/BF00398190
Longo L., Christiansen H., Christiansen N.M., Cornaglia-Ferraris P., Lampert F.
N-myc amplification at chromosome band 1p32 in neuroblastoma cells as investigated by in situ hybridization.
J. Cancer Res. Clin. Oncol. 114:636-640(1988)

PubMed=3406012
Ponzoni M., Melodia A., Cirillo C., Casalaro A., Cornaglia-Ferraris P.
Effect of cytosine arabinoside on the growth and phenotypic expression of GI-ME-N, a new human neuroblastoma cell line.
Prog. Clin. Biol. Res. 271:437-448(1988)

PubMed=3422578; DOI=10.1016/0165-4608(88)90188-4
Donti E., Longo L., Tonini G.P., Verdona G., Melodia A., Lanino E., Cornaglia-Ferraris P.
Cytogenetic and molecular study of two human neuroblastoma cell lines.
Cancer Genet. Cytogenet. 30:225-231(1988)

PubMed=2535035; DOI=10.1002/gcc.2870010111
Martinsson T., Weith A., Cziepluch C., Schwab M.
Chromosome 1 deletions in human neuroblastomas: generation and fine mapping of microclones from the distal 1p region.
Genes Chromosomes Cancer 1:67-78(1989)

PubMed=2917605; DOI=10.1016/0014-4827(89)90196-1
Ponzoni M., Lanciotti M., Melodia A., Casalaro A., Cornaglia-Ferraris P.
Morphologic and phenotypic changes of human neuroblastoma cells in culture induced by cytosine arabinoside.
Exp. Cell Res. 181:226-237(1989)

PubMed=2296463; DOI=10.1203/00006450-199001000-00001
Cornaglia-Ferraris P., Ponzoni M., Montaldo P., Mariottini G.L., Donti E., Di Martino D., Tonini G.P.
A new human highly tumorigenic neuroblastoma cell line with undetectable expression of N-myc.
Pediatr. Res. 27:1-6(1990)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

PubMed=7838528
Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=9516836; DOI=10.1016/S0959-8049(97)00319-5
Van Roy N., Laureys G., Van Gele M., Opdenakker G., Miura R., van der Drift P., Chan A., Versteeg R., Speleman F.
Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.
Eur. J. Cancer 33:1974-1978(1997)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=11550280; DOI=10.1002/gcc.1174
Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B., Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes Chromosomes Cancer 32:126-135(2001)

PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections CLS; 300179/p640_Gimen
DSMZ; ACC-654
ICLC; HTL98011
Cell line databases/resources CLDB; cl1464
CLDB; cl4931
Cosmic-CLP; 906872
GDSC; 906872
LINCS_LDP; LCL-1983
Ontologies BTO; BTO:0005808
CLO; CLO_0003494
Biological sample resources BioSample; SAMN03473467
Chemistry resources ChEMBL-Cells; CHEMBL3308868
ChEMBL-Targets; CHEMBL2366074
Gene expression databases GEO; GSM692856
GEO; GSM1669810
Polymorphism and mutation databases Cosmic; 755616
Cosmic; 906872
Cosmic; 1167992
Cosmic; 1518065
Cosmic; 1526625
Cosmic; 1543771
Cosmic; 2239471