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Cellosaurus GI-ME-N (CVCL_1232)

[Text version]

Cell line name GI-ME-N
Synonyms Gi-ME-N; GIMEN; Gimen; Gimen1; Gaslini Institute-ME-Neuroblastoma
Accession CVCL_1232
Resource Identification Initiative To cite this cell line use: GI-ME-N (RRID:CVCL_1232)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~25 hours (CLS); ~24 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.35
Native American0.42
East Asian, North0.23
East Asian, South0
South Asian7.63
European, North34.54
European, South55.82
Disease Neuroblastoma (NCIt: C3270)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RS22 (GI-ME-NrCDDP500)CVCL_RS07 (GI-ME-NrDOX5)CVCL_RR32 (GI-ME-NrVCR14)
Sex of cell Female
Age at sampling 3Y6M
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D3S135814
D5S81812
D7S82010,11
D8S117910,14
D13S31712 (CLS)
8,12 (Cosmic-CLP; DSMZ)
D16S5399,12
D18S5112,17
D21S1131
FGA19,22
Penta D9,13
Penta E15,20
TH016,7
TPOX11
vWA16,19

Run an STR similarity search on this cell line
Publications

PubMed=3615018
Melodia A., Cornara L., Bertelli R., Canepa M., Gimelli G., Repetto G., Cornaglia-Ferraris P.
New line of human neuroblastoma derived from bone marrow.
Pathologica 78:371-384(1986)

PubMed=3204111; DOI=10.1007/BF00398190
Longo L., Christiansen H., Christiansen N.M., Cornaglia-Ferraris P., Lampert F.
N-myc amplification at chromosome band 1p32 in neuroblastoma cells as investigated by in situ hybridization.
J. Cancer Res. Clin. Oncol. 114:636-640(1988)

PubMed=3406012
Ponzoni M., Melodia A., Cirillo C., Casalaro A., Cornaglia-Ferraris P.
Effect of cytosine arabinoside on the growth and phenotypic expression of GI-ME-N, a new human neuroblastoma cell line.
Prog. Clin. Biol. Res. 271:437-448(1988)

PubMed=3422578; DOI=10.1016/0165-4608(88)90188-4
Donti E., Longo L., Tonini G.P., Verdona G., Melodia A., Lanino E., Cornaglia-Ferraris P.
Cytogenetic and molecular study of two human neuroblastoma cell lines.
Cancer Genet. Cytogenet. 30:225-231(1988)

PubMed=2535035; DOI=10.1002/gcc.2870010111
Martinsson T., Weith A., Cziepluch C., Schwab M.
Chromosome 1 deletions in human neuroblastomas: generation and fine mapping of microclones from the distal 1p region.
Genes Chromosomes Cancer 1:67-78(1989)

PubMed=2917605; DOI=10.1016/0014-4827(89)90196-1
Ponzoni M., Lanciotti M., Melodia A., Casalaro A., Cornaglia-Ferraris P.
Morphologic and phenotypic changes of human neuroblastoma cells in culture induced by cytosine arabinoside.
Exp. Cell Res. 181:226-237(1989)

PubMed=2296463; DOI=10.1203/00006450-199001000-00001
Cornaglia-Ferraris P., Ponzoni M., Montaldo P., Mariottini G.L., Donti E., Di Martino D., Tonini G.P.
A new human highly tumorigenic neuroblastoma cell line with undetectable expression of N-myc.
Pediatr. Res. 27:1-6(1990)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

PubMed=7838528
Cheng N.C., Van Roy N., Chan A., Beitsma M., Westerveld A., Speleman F., Versteeg R.
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 10:291-297(1995)

PubMed=9283597; DOI=10.1016/S0165-4608(96)00362-7
Van Roy N., Jauch A., Van Gele M., Laureys G., Versteeg R., De Paepe A., Cremer T., Speleman F.
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
Cancer Genet. Cytogenet. 97:135-142(1997)

PubMed=9516836; DOI=10.1016/S0959-8049(97)00319-5
Van Roy N., Laureys G., Van Gele M., Opdenakker G., Miura R., van der Drift P., Chan A., Versteeg R., Speleman F.
Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.
Eur. J. Cancer 33:1974-1978(1997)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=11550280; DOI=10.1002/gcc.1174
Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B., Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes Chromosomes Cancer 32:126-135(2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22213050; DOI=10.1002/ijc.27415
Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J., Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=24466371; DOI=10.1593/tlo.13544
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections CLS; 300179/p640_Gimen
DSMZ; ACC-654
ICLC; HTL98011
Cell line databases/resources CLDB; cl1464
CLDB; cl4931
CCLE; GIMEN_AUTONOMIC_GANGLIA
Cell_Model_Passport; SIDM00227
Cosmic-CLP; 906872
DepMap; ACH-001344
GDSC; 906872
LINCS_LDP; LCL-1983
Ontologies BTO; BTO:0005808
CLO; CLO_0003494
Biological sample resources BioSample; SAMN03473467
Chemistry resources ChEMBL-Cells; CHEMBL3308868
ChEMBL-Targets; CHEMBL2366074
PharmacoDB; GIMEN_405_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM692856
GEO; GSM1669810
Other Wikidata; Q54835813
Polymorphism and mutation databases Cosmic; 755616
Cosmic; 906872
Cosmic; 1167992
Cosmic; 1518065
Cosmic; 1526625
Cosmic; 1543771
Cosmic; 2239471
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number26