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Cellosaurus GR-ST (CVCL_1236)

[Text version]

Cell line name GR-ST
Synonyms GRST
Accession CVCL_1236
Resource Identification Initiative To cite this cell line use: GR-ST (RRID:CVCL_1236)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
Transfected with: HGNC; 2439; CSF3R.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BRAF p.Asp361Gly (c.1082A>G) (CCLE; Cosmic-CLP).
Heterozygous for KIT p.Lys193fs*30 (c.576_580delCAAGT) (CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Met246Thr (c.737T>C) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North74.6
East Asian, South25.39
South Asian0
European, North0
European, South0
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U347 (ST [Human leukemia])
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB

Markers:
AmelogeninX
CSF1PO10,11,12
D5S81810,12 (Cosmic-CLP)
10,11,12 (RCB)
D7S82010,11
D13S31711,12
D16S53912,13 (Cosmic-CLP)
12,13,14 (RCB)
TH017,10
TPOX11
vWA14,19 (Cosmic-CLP)
14,18,19 (RCB)

Run an STR similarity search on this cell line
Publications

PubMed=7538617; DOI=10.1016/0145-2126(94)00156-5
el-Sonbaty S.S., Tsuchiya H., Watanabe M., Hochito K., Kunisada T., Shimosaka A., Matsuda I.
Exogenous expression of human granulocyte colony-stimulating factor receptor in a B-lineage acute lymphoblastic leukemia cell line: a possible model for mixed lineage leukemia.
Leuk. Res. 19:249-256(1995)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections RCB; RCB1182
Cell line databases/resources CCLE; GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01259
Cosmic-CLP; 906877
DepMap; ACH-002238
GDSC; 906877
LINCS_LDP; LCL-1045
Ontologies CLO; CLO_0050981
Biological sample resources BioSample; SAMN03472171
Chemistry resources ChEMBL-Cells; CHEMBL3308529
ChEMBL-Targets; CHEMBL2366111
PharmacoDB; GRST_413_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669816
Other Wikidata; Q54871662
Polymorphism and mutation databases Cosmic; 906877
IARC_TP53; 21350
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24