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Cellosaurus H-EMC-SS (CVCL_1238)

Cell line name H-EMC-SS
Synonyms HEMCSS; HEMC-SS
Accession CVCL_1238
Resource Identification Initiative To cite this cell line use: H-EMC-SS (RRID:CVCL_1238)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 17.3-42.8 hours (CelloPub=CLPUB00044).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Caution: Does not harbor a gene fusion involving EWSR1 which is a hallmark of extraskeletal myxoid chondrosarcoma (PubMed=34413129).
Derived from site: In situ; Muscle; UBERON=UBERON_0001630.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.61
Native American0.67
East Asian, North77.11
East Asian, South20.07
South Asian0.1
European, North0.01
European, South1.42
Disease Extraskeletal myxoid chondrosarcoma (NCIt: C27502)
Extraskeletal myxoid chondrosarcoma (ORDO: Orphanet_209916)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; RCB

Markers:
AmelogeninX
CSF1PO10,12
D3S135815,16
D5S81810,12
D7S8208,11
D8S117914,17
D13S3179 (RCB)
9,13 (Cosmic-CLP; DepMap)
D16S5399,13
D18S5116,24
D21S1130,32.2
FGA21,22
Penta D9,10
Penta E10,14
TH017,9
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

CLPUB00044
Ooshima F.
Establishment of a new cell line from human extraskeletal myxoid chondrosarcoma.
Dokkyo J. Med. Sci. 19:1-9(1992)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=34413129; DOI=10.1158/1535-7163.MCT-21-0089
Gartrell J., Mellado-Largarde M., Clay M.R., Bahrami A., Sahr N.A., Sykes A., Blankenship K., Hoffmann L., Xie J., Cho H.P., Twarog N., Connelly M., Yan K.-K., Yu J.-Y., Porter S.N., Pruett-Miller S.M., Neale G., Tinkle C.L., Federico S.M., Stewart E.A., Shelat A.A.
SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA-damaging agents.
Mol. Cancer Ther. 20:2151-2165(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 94042258
ICLC; HTL99016
RCB; RCB0508
Cell line databases/resources CLO; CLO_0003701
CLO; CLO_0051381
CLDB; cl1625
CLDB; cl4965
cancercelllines; CVCL_1238
Cell_Model_Passport; SIDM00535
Cosmic-CLP; 907290
DepMap; ACH-001519
LINCS_LDP; LCL-1458
Biological sample resources BioSample; SAMD00005690
BioSample; SAMN03472276
Chemistry resources ChEMBL-Cells; CHEMBL3308736
ChEMBL-Targets; CHEMBL1075451
GDSC; 907290
PharmacoDB; HEMCSS_419_2019
PubChem_Cell_line; CVCL_1238
Encyclopedic resources Wikidata; Q54871889
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827448
GEO; GSM1669877
Polymorphism and mutation databases Cosmic; 907290
IARC_TP53; 21353
Progenetix; CVCL_1238
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number34