Cellosaurus H4 (CVCL_1239)

Cell line name H4
Synonyms H-4
Accession CVCL_1239
Resource Identification Initiative To cite this cell line use: H4 (RRID:CVCL_1239)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: Has no IDH1 mutation (PubMed=19435942).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Miscellaneous: Originally classified as being from a neuroglioma, an obsolete classification. This cell line has been reclassified as an astrocytoma.
Disease Astrocytoma (NCIt: C60781)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_D601 (H4-APP751); CVCL_U993 (H4-C99)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; CLS; Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31712
D16S53911,12
D18S5114,16
D21S1130,31
D3S135817,18
D5S81810,12
D7S8208,11
D8S117914
FGA19,25
Penta D10,12
Penta E5,12
TH017,9
TPOX8,11
vWA14,18
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-293.html
Publications

PubMed=4544026; DOI=10.1093/jnci/52.1.71
Arnstein P., Taylor D.O.N., Nelson-Rees W.A., Huebner R.J., Lennette E.H.
Propagation of human tumors in antithymocyte serum-treated mice.
J. Natl. Cancer Inst. 52:71-84(1974)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=10074188
Arbour N., Cote G., Lachance C., Tardieu M., Cashman N.R., Talbot P.J.
Acute and persistent infection of human neural cell lines by human coronavirus OC43.
J. Virol. 73:3338-3350(1999)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11508811; DOI=10.1023/A:1010680920087
Krex D., Mohr B., Hauses M., Ehninger G., Schackert H.K., Schackert G.
Identification of uncommon chromosomal aberrations in the neuroglioma cell line H4 by spectral karyotyping.
J. Neurooncol. 52:119-128(2001)

PubMed=19435942; DOI=10.1215/15228517-2009-025
Ichimura K., Pearson D.M., Kocialkowski S., Backlund L.M., Chan R., Jones D.T.W., Collins V.P.
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; HTB-148
BCRJ; 0263
CLS; 300184/p564_H4
IZSLER; BS TCL 102
KCB; KCB 2012027YJ
Cell line databases/resources CLDB; cl5193
CCLE; H4_CENTRAL_NERVOUS_SYSTEM
CCRID; 3111C0001CCC000372
CCRID; 3142C0001000000099
Cosmic-CLP; 907042
GDSC; 907042
IGRhCellID; H4
LINCS_LDP; LCL-1401
Lonza; 285
TOKU-E; 1367
Ontologies BTO; BTO:0003704
CLO; CLO_0003599
EFO; EFO_0002184
Biological sample resources BioSample; SAMN03472722
ENCODE; ENCBS381KGR
ENCODE; ENCBS836LDB
ENCODE; ENCBS902ISQ
Chemistry resources ChEMBL-Cells; CHEMBL3308507
ChEMBL-Targets; CHEMBL1075452
Gene expression databases GEO; GSM326236
GEO; GSM887031
GEO; GSM888101
GEO; GSM1669834
Polymorphism and mutation databases Cosmic; 687571
Cosmic; 849856
Cosmic; 907042
Cosmic; 1610749
Cosmic; 1746955
Cosmic; 2060805
Cosmic; 2302320
Cosmic; 2367529