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Cellosaurus H4 (CVCL_1239)

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Cell line name H4
Synonyms H-4
Accession CVCL_1239
Resource Identification Initiative To cite this cell line use: H4 (RRID:CVCL_1239)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: PTEN genetic alteration cell panel (ATCC TCP-1030).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Miscellaneous: Originally classified as originating from a neuroglioma, an obsolete classification. This cell line has been reclassified as an astrocytoma.
Sequence variations Has no IDH1 mutation (PubMed=19435942).
Homozygous for PTEN deletion (PubMed=10560660).
TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).
Has no TP53 mutation (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.32
East Asian, North0.97
East Asian, South0
South Asian0
European, North68.05
European, South29.66
Disease Astrocytoma (NCIt: C60781)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D601 (H4-APP751)CVCL_U993 (H4-C99)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; CLS; Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133818,25
D3S135817,18
D5S81810,12
D7S8208,11
D8S11799,12 (CCRID)
14 (CLS)
D13S31712
D16S53911,12
D18S5114,16
D19S43312,14
D21S1130,31
FGA19,25
Penta D10,12
Penta E5,12
TH017,9
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-293.html
http://www.cellresource.cn/fdetail.aspx?id=867
http://www.cellresource.cn/fdetail.aspx?id=1561
Publications

PubMed=4544026; DOI=10.1093/jnci/52.1.71
Arnstein P., Taylor D.O.N., Nelson-Rees W.A., Huebner R.J., Lennette E.H.
Propagation of human tumors in antithymocyte serum-treated mice.
J. Natl. Cancer Inst. 52:71-84(1974)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=10074188
Arbour N., Cote G., Lachance C., Tardieu M., Cashman N.R., Talbot P.J.
Acute and persistent infection of human neural cell lines by human coronavirus OC43.
J. Virol. 73:3338-3350(1999)

PubMed=10560660; DOI=10.1097/00005072-199911000-00007
Schmidt E.E., Ichimura K., Goike H.M., Moshref A., Liu L., Collins V.P.
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.
J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11508811; DOI=10.1023/A:1010680920087
Krex D., Mohr B., Hauses M., Ehninger G., Schackert H.K., Schackert G.
Identification of uncommon chromosomal aberrations in the neuroglioma cell line H4 by spectral karyotyping.
J. Neurooncol. 52:119-128(2001)

PubMed=19435942; DOI=10.1215/15228517-2009-025
Ichimura K., Pearson D.M., Kocialkowski S., Backlund L.M., Chan R., Jones D.T.W., Collins V.P.
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; HTB-148
BCRJ; 0263
CCTCC; GDC0128
CLS; 300184/p564_H4
IZSLER; BS TCL 102
KCB; KCB 2012027YJ
Cell line databases/resources CLDB; cl5193
CCLE; H4_CENTRAL_NERVOUS_SYSTEM
CCRID; 3111C0001CCC000372
CCRID; 3142C0001000000099
Cell_Model_Passport; SIDM00852
Cosmic-CLP; 907042
DepMap; ACH-000389
GDSC; 907042
IGRhCellID; H4
LINCS_LDP; LCL-1401
Lonza; 285
TOKU-E; 1367
Ontologies BTO; BTO:0003704
CLO; CLO_0003599
EFO; EFO_0002184
Biological sample resources BioSample; SAMN03472722
BioSample; SAMN10987915
ENCODE; ENCBS381KGR
ENCODE; ENCBS836LDB
ENCODE; ENCBS902ISQ
Chemistry resources ChEMBL-Cells; CHEMBL3308507
ChEMBL-Targets; CHEMBL1075452
PharmacoDB; H4_437_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM326236
GEO; GSM887031
GEO; GSM888101
GEO; GSM1669834
Other Wikidata; Q54872126
Polymorphism and mutation databases Cosmic; 687571
Cosmic; 849856
Cosmic; 907042
Cosmic; 1610749
Cosmic; 1746955
Cosmic; 2060805
Cosmic; 2302320
Cosmic; 2367529
IARC_TP53; 21355
LiGeA; CCLE_383
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number27