Cellosaurus H9 (CVCL_1240)

Cell line name H9
Synonyms HT clone H9; HT(H9); H 9; H-9
Accession CVCL_1240
Resource Identification Initiative To cite this cell line use: H9 (RRID:CVCL_1240)
Comments Part of: COSMIC cell lines project.
Characteristics: Permissive for HIV-1 replication. Is accordingly used to isolate and propagate HIV-1 from the blood of patients with AIDS.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Anecdotal: For a number of years it was not known that H9 used by Gallo's lab to isolate HIV-1 (HTLV-III) was in fact a clone of Hut 78 from Minna's lab (PubMed=2567177). This created a controversy between the labs of Minna and Gallo (PubMed=2193399).
Discontinued: IZSLER; BS TCL 19; probable.
Derived from sampling site: Peripheral blood.
Disease Mycosis fungoides and Sezary syndrome (NCIt: C9265)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0337 (HuT 78)
Children:
CVCL_X680 (H9/HIV-2MVP-11971)CVCL_X681 (H9/HIV-2MVP-15132)CVCL_3514 (H9/HTLV-IIIB)
CVCL_X621 (H9/HTLV-IIICC)CVCL_X620 (H9/HTLV-IIIMN)CVCL_X619 (H9/HTLV-IIIRF)
CVCL_X610 (H9/SIVmac186)CVCL_D536 (H938)CVCL_U264 (RH9)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; ECACC; KCLB

Markers:
AmelogeninX,Y
CSF1PO11
D13S3178,12
D16S53911,12
D3S135815,16
D5S81811
D7S8208,11
FGA21,25
TH018,9
TPOX8,9
vWA14,15
Web pages http://www.nibsc.org/Default.aspx?pageid=597&id=0001&theme=default
http://www.bmj.com/rapid-response/2011/10/30/cell-lines-hut102-and-hut78
Publications

PubMed=2567177; DOI=10.1089/aid.1989.5.253
Mann D.L., O'Brien S.J., Gilbert D.A., Reid Y., Popovic M., Read-Connole E., Gallo R.C., Gazdar A.F.
Origin of the HIV-susceptible human CD4+ cell line H9.
AIDS Res. Hum. Retroviruses 5:253-255(1989)

PubMed=2193399; DOI=10.1126/science.2193399
Rubinstein E.
The untold story of HUT78.
Science 248:1499-1507(1990)

PubMed=1460674; DOI=10.1093/jnci/84.24.1922
Chen T.-R.
Karyotypic derivation of H9 cell line expressing human immunodeficiency virus susceptibility.
J. Natl. Cancer Inst. 84:1922-1926(1992)

PubMed=8320746; DOI=10.1093/jnci/85.14.1168
Bunn P.A. Jr., Whang-Peng J., Gazdar A.F., Minna J.D., Carney D.N.
Karyotypic derivation of H9 cell line.
J. Natl. Cancer Inst. 85:1168-1169(1993)

PubMed=8127147
Heyman M., Grander D., Brondum-Nielsen K., Cederblad B., Liu Y., Xu B., Einhorn S.
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Borgonovo Brandter L., Heyman M., Rasool O., Liu Y., Grander D., Einhorn S.
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; HTB-176
ECACC; 85050301
ICLC; HTL05006
IZSLER; BS TCL 19
KCB; KCB 200418YJ
KCLB; 30176
NIH-ARP; 87-436
Cell line databases/resources CLDB; cl1556
CLDB; cl1557
CLDB; cl7167
CCRID; 3142C0001000000031
Cosmic-CLP; 907043
GDSC; 907043
LINCS_LDP; LCL-1144
Lonza; 910
TOKU-E; 3613
Ontologies BTO; BTO:0001944
CLO; CLO_0003581
CLO; CLO_0003612
EFO; EFO_0003045
Biological sample resources BioSample; SAMN03472731
Chemistry resources ChEMBL-Cells; CHEMBL3308402
ChEMBL-Targets; CHEMBL614806
Gene expression databases GEO; GSM1669836
Polymorphism and mutation databases Cosmic; 687842
Cosmic; 907043
Cosmic; 933542
Cosmic; 2301568