Cellosaurus HC-1 (CVCL_1243)

Cell line name HC-1
Synonyms HC1
Accession CVCL_1243
Resource Identification Initiative To cite this cell line use: HC-1 (RRID:CVCL_1243)
Comments Problematic cell line: Possibly misidentified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
Doubling time: ~45 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Derived from sampling site: Peripheral blood.
Disease Hairy cell leukemia (NCIt: C7402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S31711,12
D16S53910,11
D5S81811,12
D7S82010,12
TH019,9.3
TPOX8
vWA15,18
Publications

PubMed=1851909
Schiller J.H., Bittner G.N., Meisner L.F., Oberley T.D., Norback D., Schwabe M., Faltynek C.R., Raab-Traub N.
Establishment and characterization of an Epstein-Barr virus spontaneously transformed lymphocytic cell line derived from a hairy cell leukemia patient.
Leukemia 5:399-407(1991)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=22653958; DOI=10.1182/blood-2011-12-400374
Tiacci E., Pucciarini A., Bigerna B., Pettirossi V., Strozzini F., Martelli M.P., Tabarrini A., Drexler H.G., Falini B.
Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.
Blood 119:5332-5333(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-301
Cell line databases/resources Cosmic-CLP; 907044
GDSC; 907044
LINCS_LDP; LCL-1086
Ontologies CLO; CLO_0003627
Biological sample resources BioSample; SAMN03473346
Chemistry resources ChEMBL-Cells; CHEMBL3308522
ChEMBL-Targets; CHEMBL2366299
Gene expression databases GEO; GSM1669840
Polymorphism and mutation databases Cosmic; 907044
Cosmic; 1809512