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Cellosaurus HC-1 (CVCL_1243)

[Text version]

Cell line name HC-1
Synonyms HC1
Accession CVCL_1243
Resource Identification Initiative To cite this cell line use: HC-1 (RRID:CVCL_1243)
Comments Problematic cell line: Possibly misidentified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Doubling time: ~45 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0.03
East Asian, South0
South Asian1.15
European, North70.39
European, South28.43
Disease Hairy cell leukemia (NCIt: C7402)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81811,12
D7S82010,12
D13S31711,12
D16S53910,11
TH019,9.3
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=1851909
Schiller J.H., Bittner G.N., Meisner L.F., Oberley T.D., Norback D., Schwabe M., Faltynek C.R., Raab-Traub N.
Establishment and characterization of an Epstein-Barr virus spontaneously transformed lymphocytic cell line derived from a hairy cell leukemia patient.
Leukemia 5:399-407(1991)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=22653958; DOI=10.1182/blood-2011-12-400374
Tiacci E., Pucciarini A., Bigerna B., Pettirossi V., Strozzini F., Martelli M.P., Tabarrini A., Drexler H.G., Falini B.
Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.
Blood 119:5332-5333(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-301
Cell line databases/resources CCLE; HC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01073
Cosmic-CLP; 907044
DepMap; ACH-002242
GDSC; 907044
LINCS_LDP; LCL-1086
Ontologies CLO; CLO_0003627
Biological sample resources BioSample; SAMN03473346
Chemistry resources ChEMBL-Cells; CHEMBL3308522
ChEMBL-Targets; CHEMBL2366299
PharmacoDB; HC1_444_2019
Gene expression databases ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1669840
Other Wikidata; Q54881463
Polymorphism and mutation databases Cosmic; 907044
Cosmic; 1809512
Cosmic; 2690009
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23