ID   HC-1
AC   CVCL_1243
SY   HC1
DR   CLO; CLO_0003627
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473346
DR   CCLE; HC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DR   Cell_Model_Passport; SIDM01073
DR   ChEMBL-Cells; CHEMBL3308522
DR   ChEMBL-Targets; CHEMBL2366299
DR   Cosmic; 907044
DR   Cosmic; 1809512
DR   Cosmic; 2690009
DR   Cosmic-CLP; 907044
DR   DepMap; ACH-002242
DR   DSMZ; ACC-301
DR   GDSC; 907044
DR   GEO; GSM1669840
DR   LINCS_LDP; LCL-1086
DR   PharmacoDB; HC1_444_2019
DR   Wikidata; Q54881463
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1851909;
RX   PubMed=20164919;
RX   PubMed=20454443;
RX   PubMed=22653958;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=31160637;
CC   Problematic cell line: Possibly misidentified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: LL-100 blood cancer cell line panel.
CC   Doubling time: ~45 hours (DSMZ).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=0.03%; East Asian, South=0%; South Asian=1.15%; European, North=70.39%; European, South=28.43% (PubMed=30894373).
CC   Derived from sampling site: Peripheral blood.
ST   Source(s): Cosmic-CLP; DSMZ
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 10,11
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 15,18
DI   NCIt; C7402; Hairy cell leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 06-09-19; Version: 23
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1851909;
RA   Schiller J.H., Bittner G.N., Meisner L.F., Oberley T.D., Norback D.,
RA   Schwabe M., Faltynek C.R., Raab-Traub N.;
RT   "Establishment and characterization of an Epstein-Barr virus
RT   spontaneously transformed lymphocytic cell line derived from a hairy
RT   cell leukemia patient.";
RL   Leukemia 5:399-407(1991).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767;
RA   Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.;
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767-904767(2010).
//
RX   PubMed=22653958; DOI=10.1182/blood-2011-12-400374;
RA   Tiacci E., Pucciarini A., Bigerna B., Pettirossi V., Strozzini F.,
RA   Martelli M.P., Tabarrini A., Drexler H.G., Falini B.;
RT   "Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M,
RT   and HC-1 questions their origin from hairy cell leukemia.";
RL   Blood 119:5332-5333(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x;
RA   Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M.,
RA   MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.;
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218-8218(2019).
//