Cellosaurus HCC1143 (CVCL_1245)

Cell line name HCC1143
Synonyms HCC-1143
Accession CVCL_1245
Resource Identification Initiative To cite this cell line use: HCC1143 (RRID:CVCL_1245)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Part of: AKT genetic alteration cell panel (ATCC TCP-1029).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~45-60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: HLA class I peptidome analysis by proteomics.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Ductal breast carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1246 ! HCC1143 BL
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; DOI=10.4172/2157-7145.S2-005; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D13S31712
D16S53911,13
D18S5114
D19S43313,16.2
D21S1130.2
D2S133820,23
D3S135816
D5S81811
D7S82012
D8S117913
FGA21
Penta D8
Penta E10
TH019.3
TPOX12
vWA16
Web pages http://www.pawefish.path.cam.ac.uk/BreastCellLineDescriptions/HCC1143.html
http://colt.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=HCC1143
http://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf
http://tcpaportal.org/mclp/
Publications

PubMed=9833771; DOI=10.1002/(SICI)1097-0215(19981209)78:6<766::AID-IJC15>3.0.CO;2-L
Gazdar A.F., Kurvari V., Virmani A.K., Gollahon L., Sakaguchi M., Westerfield M., Kodagoda D., Stasny V., Cunningham H.T., Wistuba I.I., Tomlinson G.E., Tonk V., Ashfaq R., Leitch A.M., Minna J.D., Shay J.W.
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.
Int. J. Cancer 78:766-774(1998)

PubMed=9865903
Wistuba I.I., Behrens C., Milchgrub S., Syed S., Ahmadian M., Virmani A.K., Kurvari V., Cunningham T.H., Ashfaq R., Minna J.D., Gazdar A.F.
Comparison of features of human breast cancer cell lines and their corresponding tumors.
Clin. Cancer Res. 4:2931-2938(1998)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=16959974; DOI=10.1126/science.1133427
Sjoblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
The consensus coding sequences of human breast and colorectal cancers.
Science 314:268-274(2006)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008
Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M., Ethier S.P., Gazdar A.F., Gray J.W.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=17932254; DOI=10.1126/science.1145720
Wood L.D., Parsons D.W., Jones S., Lin J., Sjoblom T., Leary R.J., Shen D., Boca S.M., Barber T.D., Ptak J., Silliman N., Szabo S., Dezso Z., Ustyanksky V., Nikolskaya T., Nikolsky Y., Karchin R., Wilson P.A., Kaminker J.S., Zhang Z., Croshaw R., Willis J., Dawson D., Shipitsin M., Willson J.K.V., Sukumar S., Polyak K., Park B.H., Pethiyagoda C.L., Pant P.V., Ballinger D.G., Sparks A.B., Hartigan J., Smith D.R., Suh E., Papadopoulos N., Buckhaults P., Markowitz S.D., Parmigiani G., Kinzler K.W., Velculescu V.E., Vogelstein B.
The genomic landscapes of human breast and colorectal cancers.
Science 318:1108-1113(2007)

PubMed=19582160; DOI=10.1371/journal.pone.0006146
Kao J., Salari K., Bocanegra M., Choi Y.-L., Girard L., Gandhi J., Kwei K.A., Hernandez-Boussard T., Wang P., Gazdar A.F., Minna J.D., Pollack J.R.
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:E6146-E6146(2009)

PubMed=21778573; DOI=10.3233/BD-2010-0307
Chavez K.J., Garimella S.V., Lipkowitz S.
Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer.
Breast Dis. 32:35-48(2010)

DOI=10.4172/2157-7145.S2-005
Fang R., Shewale J.G., Nguyen V.T., Cardoso H., Swerdel M., Hart R.P., Furtado M.R.
STR profiling of human cell lines: challenges and possible solutions to the growing problem.
J. Forensic Res. 2 Suppl. 2:5-5(2011)

PubMed=22414580; DOI=10.1158/0008-5472.CAN-11-3711
Geiger T., Madden S.F., Gallagher W.M., Cox J., Mann M.
Proteomic portrait of human breast cancer progression identifies novel prognostic markers.
Cancer Res. 72:2428-2439(2012)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23151021; DOI=10.1186/1471-2164-13-619
Grigoriadis A., Mackay A., Noel E., Wu P.J., Natrajan R., Frankum J., Reis-Filho J.S., Tutt A.
Molecular characterisation of cell line models for triple-negative breast cancers.
BMC Genomics 13:619-619(2012)

PubMed=23601657; DOI=10.1186/bcr3415
Riaz M., van Jaarsveld M.T.M., Hollestelle A., Prager-van der Smissen W.J.C., Heine A.A.J., Boersma A.W.M., Liu J., Helmijr J.C.A., Ozturk B., Smid M., Wiemer E.A., Foekens J.A., Martens J.W.M.
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33-R33(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3
Prat A., Karginova O., Parker J.S., Fan C., He X., Bixby L., Harrell J.C., Roman E., Adamo B., Troester M., Perou C.M.
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25576301; DOI=10.1074/mcp.M114.042812
Bassani-Sternberg M., Pletscher-Frankild S., Jensen L.J., Mann M.
Mass spectrometry of human leukocyte antigen class I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation.
Mol. Cell. Proteomics 14:658-673(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-2321
DSMZ; ACC-517
Cell line databases/resources CCLE; HCC1143_BREAST
Cosmic-CLP; 749710
GDSC; 749710
IGRhCellID; HCC1143
LINCS_HMS; 50205
LINCS_LDP; LCL-1329
Ontologies CLO; CLO_0003630
EFO; EFO_0001169
Biological sample resources BioSample; SAMN01821553
BioSample; SAMN01821627
BioSample; SAMN03471844
Chemistry resources ChEMBL-Cells; CHEMBL3308737
ChEMBL-Targets; CHEMBL1075453
Gene expression databases GEO; GSE82032
GEO; GSM184404
GEO; GSM184405
GEO; GSM217570
GEO; GSM274677
GEO; GSM303672
GEO; GSM303674
GEO; GSM303676
GEO; GSM303677
GEO; GSM303678
GEO; GSM303679
GEO; GSM303681
GEO; GSM303683
GEO; GSM303685
GEO; GSM303686
GEO; GSM303688
GEO; GSM303690
GEO; GSM303692
GEO; GSM303693
GEO; GSM303694
GEO; GSM303696
GEO; GSM303697
GEO; GSM303699
GEO; GSM303701
GEO; GSM303702
GEO; GSM303703
GEO; GSM303705
GEO; GSM303706
GEO; GSM303708
GEO; GSM303710
GEO; GSM303711
GEO; GSM303713
GEO; GSM303714
GEO; GSM303716
GEO; GSM303717
GEO; GSM303718
GEO; GSM303720
GEO; GSM303722
GEO; GSM303724
GEO; GSM303725
GEO; GSM303727
GEO; GSM303728
GEO; GSM303730
GEO; GSM303732
GEO; GSM303733
GEO; GSM303734
GEO; GSM303736
GEO; GSM303737
GEO; GSM303739
GEO; GSM303741
GEO; GSM303743
GEO; GSM303744
GEO; GSM303746
GEO; GSM303748
GEO; GSM303749
GEO; GSM303751
GEO; GSM303752
GEO; GSM303755
GEO; GSM303756
GEO; GSM303757
GEO; GSM303758
GEO; GSM303759
GEO; GSM303761
GEO; GSM303763
GEO; GSM303764
GEO; GSM303765
GEO; GSM303767
GEO; GSM303768
GEO; GSM303771
GEO; GSM303772
GEO; GSM303773
GEO; GSM303774
GEO; GSM303776
GEO; GSM303778
GEO; GSM303779
GEO; GSM303781
GEO; GSM303782
GEO; GSM303783
GEO; GSM303785
GEO; GSM303787
GEO; GSM303788
GEO; GSM303790
GEO; GSM337641
GEO; GSM337642
GEO; GSM337643
GEO; GSM337644
GEO; GSM337645
GEO; GSM337646
GEO; GSM337647
GEO; GSM337648
GEO; GSM337649
GEO; GSM337650
GEO; GSM337651
GEO; GSM337652
GEO; GSM337653
GEO; GSM337654
GEO; GSM337655
GEO; GSM337656
GEO; GSM337657
GEO; GSM337658
GEO; GSM337659
GEO; GSM337660
GEO; GSM337661
GEO; GSM344378
GEO; GSM344428
GEO; GSM350550
GEO; GSM481298
GEO; GSM533400
GEO; GSM533407
GEO; GSM537970
GEO; GSM783932
GEO; GSM847319
GEO; GSM844541
GEO; GSM854615
GEO; GSM854616
GEO; GSM854617
GEO; GSM854618
GEO; GSM854619
GEO; GSM887033
GEO; GSM888103
GEO; GSM1008895
GEO; GSM1053704
GEO; GSM1172954
GEO; GSM1172861
GEO; GSM1214576
GEO; GSM1215281
GEO; GSM1215282
GEO; GSM1215283
GEO; GSM1215287
GEO; GSM1215284
GEO; GSM1215285
GEO; GSM1215286
GEO; GSM1215288
GEO; GSM1374493
GEO; GSM1401661
GEO; GSM1669841
Polymorphism and mutation databases Cosmic; 749710
Cosmic; 904360
Cosmic; 1047708
Cosmic; 1176639
Cosmic; 1235079
Cosmic; 1287934
Cosmic; 1430347
Cosmic; 1460230
Cosmic; 1473032
Cosmic; 1518109
Cosmic; 1603198
Cosmic; 1935003
Cosmic; 2009509
Cosmic; 2164989
Proteomic databases PRIDE; PXD000309
PRIDE; PXD000394
PRIDE; PXD002486