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Cellosaurus HCC4006 (CVCL_1269)

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Cell line name HCC4006
Synonyms HCC-4006
Accession CVCL_1269
Resource Identification Initiative To cite this cell line use: HCC4006 (RRID:CVCL_1269)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: EGFR genetic alteration cell panel (ATCC TCP-1027).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations EGFR p.Leu747_Glu749del.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.52
Native American0
East Asian, North5.13
East Asian, South0
South Asian0
European, North54.8
European, South38.54
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S698 (HCC4006-GR-high)CVCL_S699 (HCC4006-GR-step)CVCL_S746 (HCC4006/R)
CVCL_RS46 (HCC4006rERLO1mUM)CVCL_RS47 (HCC4006rGEFI1muM)
Sex of cell Male
Age at sampling >50Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; PubMed=20679594; PubMed=25877200

Markers:
AmelogeninX (AddexBio; ATCC; PubMed=25877200)
X,Y (PubMed=20679594)
CSF1PO10
D3S135818
D5S81812
D7S8209,12
D8S117910,14
D13S31711,12
D16S53911,12 (AddexBio; ATCC; PubMed=20679594)
12 (PubMed=25877200)
D18S5119
D21S1131
FGA21,22
Penta D9,14
Penta E7,13
TH017
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Web pages http://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf
Publications

PubMed=20679594; DOI=10.1093/jnci/djq279
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112
Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.H., Diao L., Masrorpour F., Shen L., Liu W., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer Discov. 2:798-811(2012)

PubMed=23733853; DOI=10.1101/gr.152322.112
Jia P., Jin H., Meador C.B., Xia J., Ohashi K., Liu L., Pirazzoli V., Dahlman K.B., Politi K., Michor F., Zhao Z., Pao W.
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003
Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C., Daub H.
Comparative proteome analysis across non-small cell lung cancer cell lines.
J. Proteomics 130:1-10(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections AddexBio; C0016012/4917
ATCC; CRL-2871
Cell line databases/resources CCLE; HCC4006_LUNG
Cell_Model_Passport; SIDM01596
DepMap; ACH-000066
IGRhCellID; HCC4006GEO
Ontologies BTO; BTO:0004081
CLO; CLO_0003657
EFO; EFO_0003132
Biological sample resources BioSample; SAMN03471807
BioSample; SAMN03473288
BioSample; SAMN10988526
Chemistry resources PharmacoDB; HCC4006_502_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM63351
GEO; GSM253408
GEO; GSM434286
GEO; GSM794399
GEO; GSM844552
GEO; GSM887055
GEO; GSM888125
Other Wikidata; Q54881724
Polymorphism and mutation databases Cosmic; 903602
Cosmic; 1028938
Cosmic; 1128250
Cosmic; 1146936
Cosmic; 1802302
Cosmic; 2015233
LiGeA; CCLE_139
Proteomic databases PRIDE; PXD002556
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24