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Cellosaurus HCE-4 (CVCL_1271)

[Text version]

Cell line name HCE-4
Synonyms HCE4
Accession CVCL_1271
Resource Identification Initiative To cite this cell line use: HCE-4 (RRID:CVCL_1271)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Doubling time: 48 hours (PubMed=2415247).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Esophagus.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly245Val (c.734G>T); ClinVar=VCV000376603; Zygosity=Homozygous (PubMed=2263646; Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North0.25
East Asian, South0
South Asian0
European, North1.6
European, South4.77
Disease Esophageal squamous cell carcinoma (NCIt: C4024)
Squamous cell carcinoma of the esophagus (ORDO: Orphanet_99977)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5138 ! HCE-7
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP


Run an STR similarity search on this cell line

Banks-Schlegel S.P., Quintero J.
Growth and differentiation of human esophageal carcinoma cell lines.
Cancer Res. 46:250-258(1986)

PubMed=2420787; DOI=10.1016/S0021-9258(17)38506-X
Banks-Schlegel S.P., Quintero J.
Human esophageal carcinoma cells have fewer, but higher affinity epidermal growth factor receptors.
J. Biol. Chem. 261:4359-4362(1986)

PubMed=2263646; DOI=10.1073/pnas.87.24.9958
Hollstein M.C., Metcalf R.A., Welsh J.A., Montesano R., Harris C.C.
Frequent mutation of the p53 gene in human esophageal cancer.
Proc. Natl. Acad. Sci. U.S.A. 87:9958-9961(1990)

PubMed=2302677; DOI=10.1016/0165-4608(90)90073-j
Whang-Peng J., Banks-Schlegel S.P., Lee E.C.
Cytogenetic studies of esophageal carcinoma cell lines.
Cancer Genet. Cytogenet. 45:101-120(1990)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045
Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P., Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H., Harris C.C.
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line databases/resources Cell_Model_Passport; SIDM00052
Cosmic-CLP; 753559
DepMap; ACH-002243
Anatomy/cell type resources BTO; BTO:0005572
Chemistry resources ChEMBL-Cells; CHEMBL3308199
ChEMBL-Targets; CHEMBL2366207
GDSC; 753559
PharmacoDB; HCE4_514_2019
Encyclopedic resources Wikidata; Q54881849
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM482501
GEO; GSM1669865
Polymorphism and mutation databases Cosmic; 753559
Cosmic; 923186
Cosmic; 934539
Cosmic; 1394519
IARC_TP53; 258
Progenetix; CVCL_1271
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number29