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Cellosaurus HCE-4 (CVCL_1271)

[Text version]

Cell line name HCE-4
Synonyms HCE4
Accession CVCL_1271
Resource Identification Initiative To cite this cell line use: HCE-4 (RRID:CVCL_1271)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 48 hours (PubMed=2415247).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African93.38
Native American0
East Asian, North0.25
East Asian, South0
South Asian0
European, North1.6
European, South4.77
Disease Esophageal squamous cell carcinoma (NCIt: C4024)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX
CSF1PO12
D5S81810
D7S8208,11
D13S31712
D16S5399
TH018
TPOX7,8
vWA16,20

Run an STR similarity search on this cell line
Publications

PubMed=2415247
Banks-Schlegel S.P., Quintero J.
Growth and differentiation of human esophageal carcinoma cell lines.
Cancer Res. 46:250-258(1986)

PubMed=2420787
Banks-Schlegel S.P., Quintero J.
Human esophageal carcinoma cells have fewer, but higher affinity epidermal growth factor receptors.
J. Biol. Chem. 261:4359-4362(1986)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line databases/resources CCLE; HCE4_OESOPHAGUS
Cell_Model_Passport; SIDM00052
Cosmic-CLP; 753559
DepMap; ACH-002243
GDSC; 753559
LINCS_LDP; LCL-1563
Ontologies BTO; BTO:0005572
Chemistry resources ChEMBL-Cells; CHEMBL3308199
ChEMBL-Targets; CHEMBL2366207
PharmacoDB; HCE4_514_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM482501
GEO; GSM1669865
Other Wikidata; Q54881849
Polymorphism and mutation databases Cosmic; 753559
Cosmic; 923186
Cosmic; 934539
Cosmic; 1394519
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24