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Cellosaurus HCE-T (CVCL_1272)

[Text version]

Cell line name HCE-T
Synonyms HCET; Human Corneal Epithelial cells-Transformed; HCE; SV40-HCEC
Accession CVCL_1272
Resource Identification Initiative To cite this cell line use: HCE-T (RRID:CVCL_1272)
Comments Doubling time: 24.4 hours (PubMed=7534282).
Transformant: Ad-SV40.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 49Y
Category Transformed cell line
STR profile Source(s): PubMed=26900324; PubMed=29787296; RCB

Markers:
AmelogeninX
CSF1PO9,12 (PubMed=26900324)
12 (RCB; PubMed=29787296)
D2S133819,20
D3S135815,17
D5S8189,13 (PubMed=26900324; PubMed=29787296)
13 (RCB)
D7S82010,13
D8S117911,13
D13S3178
D16S5399,11
D18S5113,15 (PubMed=26900324)
13 (PubMed=29787296)
D19S43313,14
D21S1127,30
FGA20
Penta D12,15
Penta E15,16
TH017,8
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=7534282
Araki-Sasaki K., Ohashi Y., Sasabe T., Hayashi K., Watanabe H., Tano Y., Handa H.
An SV40-immortalized human corneal epithelial cell line and its characterization.
Invest. Ophthalmol. Vis. Sci. 36:614-621(1995)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=26900324
Akin D., Newman J.R.B., McIntyre L.M., Sugrue S.P.
RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells.
Mol. Vis. 22:40-60(2016)

PubMed=28315467; DOI=10.1016/j.ejps.2017.03.018
Juretic M., Jurisic Dukovski B., Krtalic I., Reichl S., Cetina-Cizmek B., Filipovic-Grcic J., Lovric J., Pepic I.
HCE-T cell-based permeability model: a well-maintained or a highly variable barrier phenotype?
Eur. J. Pharm. Sci. 104:23-30(2017)

PubMed=29787296; DOI=10.1080/02713683.2018.1480043
McDermott A.M., Baidouri H., Woodward A.M., Kam W.R., Liu Y., Chen X., Ziemanski J.F., Vistisen K., Hazlett L.D., Nichols K.K., Argueso P., Sullivan D.A.
Short tandem repeat (STR) profiles of commonly used human ocular surface cell lines.
Curr. Eye Res. 43:1097-1101(2018)

Cross-references
Cell line collections BCRJ; 0349
RCB; RCB1384 - Discontinued
RCB; RCB2280
Cell line databases/resources Cell_Model_Passport; SIDM00075
LINCS_LDP; LCL-1047
Ontologies CLO; CLO_0050405
CLO; CLO_0050406
Biological sample resources BioSample; SAMN03472134
Chemistry resources ChEMBL-Cells; CHEMBL3308200
ChEMBL-Targets; CHEMBL2366139
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSE73060
GEO; GSM1669867
Other Wikidata; Q54881856
Polymorphism and mutation databases Cosmic; 907049
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number16