ID   HCE-T
AC   CVCL_1272
SY   HCET; Human Corneal Epithelial cells-Transformed; HCE; SV40-HCEC
DR   BTO; BTO:0006396
DR   CLO; CLO_0050405
DR   CLO; CLO_0050406
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BCRJ; 0349
DR   BioSample; SAMN03472134
DR   Cell_Model_Passport; SIDM00075
DR   ChEMBL-Cells; CHEMBL3308200
DR   ChEMBL-Targets; CHEMBL2366139
DR   Cosmic; 907049
DR   DepMap; ACH-002336
DR   EGA; EGAS00001000978
DR   FCS-free; 4-2-4-2-4-3
DR   FCS-free; 4-2-6-1-4-3
DR   GEO; GSE73060
DR   GEO; GSM1669867
DR   IARC_TP53; 27695
DR   LINCS_LDP; LCL-1047
DR   PharmacoDB; HCET_516_2019
DR   PubChem_Cell_line; CVCL_1272
DR   RCB; RCB1384
DR   RCB; RCB2280
DR   Wikidata; Q54881856
RX   DOI=10.22028/D291-35665;
RX   PubMed=7534282;
RX   PubMed=20164919;
RX   PubMed=26900324;
RX   PubMed=28315467;
RX   PubMed=29787296;
RX   PubMed=31927639;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Doubling time: 24.4 hours (PubMed=7534282).
CC   Transformant: Ad-SV40 hybrid virus.
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Discontinued: BCRJ; 0349; probable.
CC   Discontinued: RCB; RCB1384; probable.
CC   Derived from site: In situ; Eye, cornea, epithelium; UBERON=UBERON_0001772.
CC   Cell type: Epithelial cell of cornea; CL=CL_0000575.
ST   Source(s): PubMed=26900324; PubMed=29787296; RCB
ST   Amelogenin: X
ST   CSF1PO: 9,12 (PubMed=26900324)
ST   CSF1PO: 12 (RCB; PubMed=29787296)
ST   D13S317: 8
ST   D16S539: 9,11
ST   D18S51: 13 (PubMed=29787296)
ST   D18S51: 13,15 (PubMed=26900324)
ST   D19S433: 13,14
ST   D21S11: 27,30
ST   D2S1338: 19,20
ST   D3S1358: 15,17
ST   D5S818: 9,13 (PubMed=26900324; PubMed=29787296)
ST   D5S818: 13 (RCB)
ST   D7S820: 10,13
ST   D8S1179: 11,13
ST   FGA: 20
ST   Penta D: 12,15
ST   Penta E: 15,16
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 18,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   49Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
//
RX   DOI=10.22028/D291-35665;
RA   Rubelowski A.-K.;
RT   "Characterization of the HCE-T cell line (RCB 2280) and its comparison
RT   with primary limbal epithelial cell culture and primary corneal
RT   epithelial cells.";
RL   Thesis MD (2018), Saarland University, Germany.
//
RX   PubMed=7534282;
RA   Araki-Sasaki K., Ohashi Y., Sasabe T., Hayashi K., Watanabe H.,
RA   Tano Y., Handa H.;
RT   "An SV40-immortalized human corneal epithelial cell line and its
RT   characterization.";
RL   Invest. Ophthalmol. Vis. Sci. 36:614-621(1995).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=26900324;
RA   Akin D., Newman J.R.B., McIntyre L.M., Sugrue S.P.;
RT   "RNA-seq analysis of impact of PNN on gene expression and alternative
RT   splicing in corneal epithelial cells.";
RL   Mol. Vis. 22:40-60(2016).
//
RX   PubMed=28315467; DOI=10.1016/j.ejps.2017.03.018;
RA   Juretic M., Jurisic Dukovski B., Krtalic I., Reichl S.,
RA   Cetina-Cizmek B., Filipovic-Grcic J., Lovric J., Pepic I.;
RT   "HCE-T cell-based permeability model: a well-maintained or a highly
RT   variable barrier phenotype?";
RL   Eur. J. Pharm. Sci. 104:23-30(2017).
//
RX   PubMed=29787296; DOI=10.1080/02713683.2018.1480043;
RA   McDermott A.M., Baidouri H., Woodward A.M., Kam W.R., Liu Y., Chen X.-M.,
RA   Ziemanski J.F., Vistisen K., Hazlett L.D., Nichols K.K., Argueso P.,
RA   Sullivan D.A.;
RT   "Short tandem repeat (STR) profiles of commonly used human ocular
RT   surface cell lines.";
RL   Curr. Eye Res. 43:1097-1101(2018).
//
RX   PubMed=31927639; DOI=10.1007/s00417-019-04563-0;
RA   Rubelowski A.-K., Latta L., Katiyar P., Stachon T., Kasmann-Kellner B.,
RA   Seitz B., Szentmary N.;
RT   "HCE-T cell line lacks cornea-specific differentiation markers
RT   compared to primary limbal epithelial cells and differentiated
RT   corneal epithelium.";
RL   Graefes Arch. Clin. Exp. Ophthalmol. 258:565-575(2020).
//