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Cellosaurus HEC-1 (CVCL_1274)

Cell line name HEC-1
Synonyms HEC1; Human Endometrial Cancer-1; HEC-B-296
Accession CVCL_1274
Resource Identification Initiative To cite this cell line use: HEC-1 (RRID:CVCL_1274)
Comments Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Microsatellite instability: Instable (MSI-high) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0293 (HEC-1-A)CVCL_S835 (HEC-1C)CVCL_S836 (HEC-1D)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO10,12
D13S31711,16 (Cosmic-CLP)
11 (JCRB)
D16S53911,12
D5S81811,13
D7S82011
TH016,7
TPOX11
vWA18
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=4673779; DOI=10.1016/0002-9378(72)90861-7
Kuramoto H., Tamura S., Notake Y.
Establishment of a cell line of human endometrial adenocarcinoma in vitro.
Am. J. Obstet. Gynecol. 114:1012-1019(1972)

PubMed=4678779
Kuramoto H.
Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line.
Nihon Sanka Fujinka Gakkai Zasshi 19:47-58(1972)

PubMed=7448794
Gal D., MacDonald P.C., Porter J.C., Smith J.W., Simpson E.R.
Effect of cell density and confluency on cholesterol metabolism in cancer cells in monolayer culture.
Cancer Res. 41:473-477(1981)

PubMed=2064198; DOI=10.1111/j.1749-6632.1991.tb37884.x
Kuramoto H., Nishida M., Morisawa T., Hamano M., Hata H., Kato Y., Ohno E., Iida T.
Establishment and characterization of human endometrial cancer cell lines.
Ann. N. Y. Acad. Sci. 622:402-421(1991)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=12227503; DOI=10.1111/j.1749-0774.2002.tb00103.x
Kurarmoto H., Hamano M., Imai M.
HEC-1 cells.
Hum. Cell 15:81-95(2002)

DOI=10.1007/978-4-431-53981-0_1
Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T., Kawaguchi M.
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
(In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo (2003)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections JCRB; JCRB0042
Cell line databases/resources Cosmic-CLP; 907051
GDSC; 907051
LINCS_HMS; 50014
LINCS_LDP; LCL-1496
Biological sample resources BioSample; SAMN03472810
Chemistry resources ChEMBL-Cells; CHEMBL3308740
ChEMBL-Targets; CHEMBL1075462
Gene expression databases GEO; GSM827285
GEO; GSM1669873
Polymorphism and mutation databases Cosmic; 907051