Cellosaurus HGC-27 (CVCL_1279)

Cell line name HGC-27
Synonyms HGC27
Accession CVCL_1279
Resource Identification Initiative To cite this cell line use: HGC-27 (RRID:CVCL_1279)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: JFCR45 cancer cell line panel.
Doubling time: ~17 hours, at 21th passage (PubMed=136873).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Gastric carcinoma (NCIt: C4911)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex undetermined
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; ECACC; PubMed=11416159; PubMed=25877200; RCB

Markers:
AmelogeninX
CSF1PO12
D13S31710,11
D16S53910,11
D18S5116,17 (CLS; PubMed=25877200)
16 (PubMed=11416159)
D21S1130,33,34
D3S135817
D5S81812
D7S82011,12,13
D8S11797,11,16 (CLS)
11 (PubMed=11416159; PubMed=25877200)
FGA22
Penta D9,13
Penta E18
TH019
TPOX8
vWA14
Publications

PubMed=136873
Akagi T., Kimoto T.
Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer.
Acta Med. Okayama 30:215-219(1976)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections BCRJ; 0310
CLS; 300436/p606_HGC-27
ECACC; 94042256
ICLC; HTL95028
RCB; RCB0500
Cell line databases/resources CLDB; cl1673
CLDB; cl1674
CCLE; HGC27_STOMACH
CCRID; 3111C0001CCC000279
CCRID; 3131C0001000700022
Cosmic-CLP; 907055
GDSC; 907055
LINCS_LDP; LCL-1882
Ontologies BTO; BTO:0004828
CLO; CLO_0003739
CLO; CLO_0050799
EFO; EFO_0006581
Biological sample resources BioSample; SAMN03472940
Chemistry resources ChEMBL-Cells; CHEMBL3308741
ChEMBL-Targets; CHEMBL1075463
Gene expression databases GEO; GSM827366
GEO; GSM844558
GEO; GSM887081
GEO; GSM888151
GEO; GSM1374533
GEO; GSM1374534
GEO; GSM1669881
Polymorphism and mutation databases Cosmic; 907055
Cosmic; 1001653
Cosmic; 1007604
Cosmic; 1187274
Cosmic; 1518247
Cosmic; 1995440
Cosmic; 2484952