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Cellosaurus HMV-II (CVCL_1282)

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Cell line name HMV-II
Synonyms HMV-2; HMVII; Human Melanoma Vagina-II
Accession CVCL_1282
Resource Identification Initiative To cite this cell line use: HMV-II (RRID:CVCL_1282)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for BRAF p.Gly469Val (c.1406G>T) (Cosmic-CLP).
Heterozygous for NRAS p.Gln61Lys (c.181C>A) (PubMed=12068308; PubMed=15467732; Cosmic-CLP).
Heterozygous for TP53 p.Asn268Ile (c.803A>T) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.4
Native American0
East Asian, North76.31
East Asian, South21.9
South Asian0.25
European, North0.78
European, South0.36
Disease Vaginal melanoma (NCIt: C27394)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=25877200; RCB; TKG

Markers:
AmelogeninX
CSF1PO13
D3S135814,15
D5S81812
D7S8208,14
D8S117910
D13S31711
D16S53911
D18S5115
D21S1129
FGA23
Penta D11
Penta E5,21
TH016,9
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=2166075
Moriuchi H., Oshima T., Nishimura H., Nakamura K., Katsushima N., Numazaki Y.
Human malignant melanoma cell line (HMV-II) for isolation of influenza C and parainfluenza viruses.
J. Clin. Microbiol. 28:1147-1150(1990)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Tanami H., Imoto I., Hirasawa A., Yuki Y., Sonoda I., Inoue J., Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections BCRJ; 0316
ECACC; 92042701
RCB; RCB0777
RCB; RCB3685
TKG; TKG 0318
Cell line databases/resources CLDB; cl1700
CCLE; HMVII_SKIN
Cell_Model_Passport; SIDM00291
CGH-DB; 9289-4
Cosmic-CLP; 907058
DepMap; ACH-002040
GDSC; 907058
LINCS_LDP; LCL-1285
Ontologies BTO; BTO:0002918
CLO; CLO_0003786
CLO; CLO_0050086
Biological sample resources BioSample; SAMN03472908
Chemistry resources ChEMBL-Cells; CHEMBL3308667
ChEMBL-Targets; CHEMBL614826
PharmacoDB; HMVII_555_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827367
GEO; GSM1669886
Other Wikidata; Q54889975
Polymorphism and mutation databases Cosmic; 688044
Cosmic; 874383
Cosmic; 905203
Cosmic; 907058
Cosmic; 1007155
Cosmic; 1477417
Cosmic; 2230117
IARC_TP53; 21375
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number28