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Cellosaurus HO-1-N-1 (CVCL_1284)

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Cell line name HO-1-N-1
Synonyms Ho-1-N-1; Ho-1-n-1; HO1-N-1; HO1-N1; HO1N1; Nakata-1
Accession CVCL_1284
Resource Identification Initiative To cite this cell line use: HO-1-N-1 (RRID:CVCL_1284)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~31 hours (lot 08212015) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North77.94
East Asian, South20.55
South Asian0.47
European, North1.04
European, South0
Disease Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO12
D5S8189
D7S82010,13
D13S31710,11
D16S5399,11
TH019
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Publications

CLPUB00049
Moroyama T., Miyauchi S., Akemi T., Sugata T., Takada K.
Establishment and characterization of a human tumor cell line (Nakata-1) derived from squamous carcinoma of the buccal mucosa.
Proc. Jpn. Cancer Assoc. 45:242-242(1986)

DOI=10.5794/jjoms.34.7
Miyauchi S., Moroyama T., Takada K.
Production of interleukin-1 like factor by human tumor cell line established from squamous cell carcinoma of the buccal mucosa.
Nihon Koku Geka Gakkai Zasshi 34:7-14(1988)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=12738951; DOI=10.1067/moe.2003.36
Sugiyama M., Bhawal U.K., Dohmen T., Ono S., Miyauchi M., Ishikawa T.
Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0831
Cell line databases/resources CCLE; HO1N1_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00592
CGH-DB; 372-2
Cosmic-CLP; 924111
DepMap; ACH-002244
GDSC; 924111
LINCS_LDP; LCL-1204
Ontologies BTO; BTO:0005771
Biological sample resources BioSample; SAMN03472524
Chemistry resources ChEMBL-Cells; CHEMBL3308743
ChEMBL-Targets; CHEMBL1075466
PharmacoDB; HO1N1_559_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827187
GEO; GSM1669888
Other Wikidata; Q54890082
Polymorphism and mutation databases Cosmic; 924111
Cosmic; 1118793
Cosmic; 1120708
Cosmic; 1530741
Cosmic; 1571801
Cosmic; 2266787
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number27