Cellosaurus HSC-3 (CVCL_1288)

Cell line name HSC-3
Synonyms HSC 3; HSC3
Accession CVCL_1288
Resource Identification Initiative To cite this cell line use: HSC-3 (RRID:CVCL_1288)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 20 hours (PubMed=24627082).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_8323 (HSC-3-M3); CVCL_JF94 (HSC-3/CMV-Luc); CVCL_W514 (LMF3); CVCL_W515 (LMF4); CVCL_W516 (LMF5)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=11416159; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO11
D13S31712
D16S5399
D18S5115
D21S1130,31.2
D5S81811,13
D7S82013
D8S117912
FGA22,26
TH016,9.3
TPOX8
vWA14,17
Publications

PubMed=2585303; DOI=10.1111/j.1600-0714.1989.tb01570.x
Momose F., Araida T., Negishi A., Ichijo H., Shioda S., Sasaki S.
Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.
J. Oral Pathol. Med. 18:391-395(1989)

PubMed=2228902; DOI=10.1007/BF02624609
Rikimaru K., Toda H., Tachikawa N., Kamata N., Enomoto S.
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
In Vitro Cell. Dev. Biol. 26:849-856(1990)

PubMed=7591301; DOI=10.1002/ijc.2910640504
Eura M., Ogi K., Chikamatsu K., Lee K.D., Nakano K., Masuyama K., Itoh K., Ishikawa T.
Expression of the MAGE gene family in human head-and-neck squamous-cell carcinomas.
Int. J. Cancer 64:304-308(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=11755821; DOI=10.1016/S1368-8375(01)00022-7
Niinaka Y., Haga A., Negishi A., Yoshimasu H., Raz A., Amagasa T.
Regulation of cell motility via high and low affinity autocrine motility factor (AMF) receptor in human oral squamous carcinoma cells.
Oral Oncol. 38:49-55(2002)

PubMed=16127291; DOI=10.1159/000087910
Bhawal U.K., Ozaki Y., Nishimura M., Sugiyama M., Sasahira T., Nomura Y., Sato F., Fujimoto K., Sasaki N., Ikeda M.A., Tsuji K., Kuniyasu H., Kato Y.
Association of expression of receptor for advanced glycation end products and invasive activity of oral squamous cell carcinoma.
Oncology 69:246-255(2005)

PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x
Kozaki K.-I., Imoto I., Pimkhaokham A., Hasegawa S., Tsuda H., Omura K., Inazawa J.
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Cancer Sci. 97:1351-1358(2006)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
Nakaya K., Yamagata H.D., Arita N., Nakashiro K.-I., Nose M., Miki T., Hamakawa H.
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24627082; DOI=10.3892/ijo.2014.2332
Fujinaga T., Kumamaru W., Sugiura T., Kobayashi Y., Ohyama Y., Ikari T., Onimaru M., Akimoto N., Jogo R., Mori Y.
Biological characterization and analysis of metastasis-related genes in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the mandibular gingiva.
Int. J. Oncol. 44:1614-1624(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0623
RCB; RCB1975
TKG; TKG 0484
Cell line databases/resources CCLE; HSC3_UPPER_AERODIGESTIVE_TRACT
CGH-DB; 364-2
Cosmic-CLP; 907061
GDSC; 907061
LINCS_LDP; LCL-1217
Ontologies BTO; BTO:0002025
CLO; CLO_0051569
Biological sample resources BioSample; SAMN01821684
BioSample; SAMN03471639
Chemistry resources ChEMBL-Cells; CHEMBL3307947
ChEMBL-Targets; CHEMBL612279
Gene expression databases GEO; GSM301579
GEO; GSM827234
GEO; GSM850383
GEO; GSM887134
GEO; GSM888205
GEO; GSM950317
GEO; GSM950318
GEO; GSM950319
GEO; GSM950320
GEO; GSM1669904
Polymorphism and mutation databases Cosmic; 907061
Cosmic; 930331
Cosmic; 932148
Cosmic; 1042299
Cosmic; 1046028
Cosmic; 1118789
Cosmic; 1120698
Cosmic; 1123039
Cosmic; 1140781
Cosmic; 1219865
Cosmic; 1530744
Cosmic; 1571802
Cosmic; 2266784
Cosmic; 2546836