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Cellosaurus HuH-6 Clone 5 (CVCL_1296)

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Cell line name HuH-6 Clone 5
Synonyms HuH-6 clone-5; HUH-6 Clone 5; HUH-6-clone 5; HUH-6-clone5; HuH-6 cl-5; HuH-6-cl5; HUH6-Cl-5; HuH-6 cl5; HuH6-Cl5; HUH6 Cl5; HUH6 CL5; Huh6cl5; HuH6-C15; Huh6-c15; HUH6 C15; Huh6c15; JTC38; JTC-38; Japanese Tissue Culture-38
Accession CVCL_1296
Resource Identification Initiative To cite this cell line use: HuH-6 Clone 5 (RRID:CVCL_1296)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 38-55 hours (lot 12142012), 35 hours (lot 05262008), ~37 hours (lot 07222016) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Sequence variations Heterozygous for CTNNB1 p.Gly34Val (c.101G>T) (from parent cell line).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.77
Native American1.36
East Asian, North76.85
East Asian, South16.52
South Asian0
European, North0
European, South3.49
Disease Hepatoblastoma (NCIt: C3728)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4381 (HuH-6)
Children:
CVCL_6907 (HB611)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S8188,11
D7S82011,12
D13S3178,12
D16S53910,11
TH017,8
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=57894
Doi I.
Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma.
Gann 67:1-10(1976)

PubMed=6161524; DOI=10.18926/AMO/30534
Miyamoto K., Taketa K., Yabe T., Miyano K., Sato J.
Chromosome analysis in a human hepato-blastoma cell line producing alpha-fetoprotein.
Acta Med. Okayama 34:127-130(1980)

PubMed=6290537; DOI=10.1172/JCI110701
Amuro Y., Tanaka M., Higashino K., Hayashi E., Endo T., Kishimoto S., Nakabayashi H., Sato J.
Bile acid synthesis by long-term cultured cell line established from human hepatoblastoma.
J. Clin. Invest. 70:1128-1130(1982)

PubMed=6301464; DOI=10.1016/0006-291X(83)91037-9
Tanaka M., Kawamura K., Fang M., Higashino K., Kishimoto S., Nakabayashi H., Sato J.
Production of fibronectin by HUH6 C15 cell line established from a human hepatoblastoma.
Biochem. Biophys. Res. Commun. 110:837-841(1983)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0401
Cell line databases/resources CCLE; HUH6CLONE5
Cell_Model_Passport; SIDM01257
Cosmic-CLP; 907070
DepMap; ACH-002395
GDSC; 907070
Biological sample resources BioSample; SAMN03471623
Chemistry resources ChEMBL-Cells; CHEMBL3308701
PharmacoDB; HUH6clone5_639_2019
Other Wikidata; Q54896849
Polymorphism and mutation databases Cosmic; 907070
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23