ID   HuO-3N1
AC   CVCL_1297
SY   HuO3N1; HUO3N1
DR   BTO; BTO:0002431
DR   CLO; CLO_0050099
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03471625
DR   cancercelllines; CVCL_1297
DR   Cell_Model_Passport; SIDM00584
DR   ChEMBL-Cells; CHEMBL3308818
DR   ChEMBL-Targets; CHEMBL1075475
DR   Cosmic; 909977
DR   Cosmic-CLP; 909977
DR   DepMap; ACH-002142
DR   EGA; EGAS00001000978
DR   GDSC; 909977
DR   GEO; GSM320824
DR   GEO; GSM1669920
DR   IARC_TP53; 21389
DR   JCRB; JCRB0413
DR   LINCS_LDP; LCL-1422
DR   PharmacoDB; HuO3N1_642_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1297
DR   RCB; RCB2104
DR   TKG; TKG 0452
DR   Wikidata; Q54896886
RX   PubMed=3862491;
RX   PubMed=20164919;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Characteristics: Established from a xenograft established in a nude mice.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ala76fs*73 (c.225_226insT); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=1.58%; Native American=0%; East Asian, North=72.02%; East Asian, South=23.28%; South Asian=1.73%; European, North=1.15%; European, South=0.24% (PubMed=30894373).
CC   Derived from site: In situ; Bone; UBERON=UBERON_0002481.
ST   Source(s): Cosmic-CLP; JCRB; RCB; TKG
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 9,10
ST   D16S539: 12
ST   D5S818: 10,12
ST   D7S820: 11,12
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 14,16
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 35
//
RX   PubMed=3862491; DOI=10.1097/00003086-198510000-00038;
RA   Yamane T.;
RT   "Establishment and characterization of cell lines derived from a human
RT   osteosarcoma.";
RL   Clin. Orthop. Relat. Res. 199:261-271(1985).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//