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Cellosaurus HuO9 (CVCL_1298)

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Cell line name HuO9
Synonyms Huo9; HUO9; Hu09
Accession CVCL_1298
Resource Identification Initiative To cite this cell line use: HuO9 (RRID:CVCL_1298)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 43.3 hours (PubMed=14669798).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Has no TP53 mutation (PubMed=9359923).
HLA typing Source: PubMed=15289353
Class I
HLA-AA*24:01,33:03
HLA-BB*44:03:01,51:01
HLA-CC*14:02,14:03
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.89
Native American0
East Asian, North77.77
East Asian, South13.74
South Asian0
European, North1.78
European, South3.83
Disease Osteosarcoma (NCIt: C9145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WL11 (HuO9-H3)CVCL_WL12 (HuO9-L12)CVCL_WL13 (HuO9-L13)
CVCL_WL14 (HuO9-L6)CVCL_R725 (HuO9-M112)CVCL_R726 (HuO9-M132)
CVCL_JG37 (HuO9/CMV-Luc)
Originate from same individual CVCL_2958 ! HuO9N2
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO10,11
D5S81813
D7S82010
D13S31711
D16S53911
TH019
TPOX9
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=2691514; DOI=10.1007/BF00391353
Kawai A., Ozaki T., Ikeda S., Oda T., Miyazaki M., Sato J., Taketa K., Inoue H.
Two distinct cell lines derived from a human osteosarcoma.
J. Cancer Res. Clin. Oncol. 115:531-536(1989)

DOI=10.11418/jtca1981.16.3_173
Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ohashi R., Namba M.
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-I., Ishioka C., Namba M.
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)

PubMed=12405284; DOI=10.1023/A:1020395816633
Kimura K., Nakano T., Park Y.-B., Tani M., Tsuda H., Beppu Y., Moriya H., Yokota J.
Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma.
Clin. Exp. Metastasis 19:477-485(2002)

PubMed=14669798; DOI=10.1023/A:1027355610603
Nakano T., Tani M., Ishibashi Y., Kimura K., Park Y.-B., Imaizumi N., Tsuda H., Aoyagi K., Sasaki H., Ohwada S., Yokota J.
Biological properties and gene expression associated with metastatic potential of human osteosarcoma.
Clin. Exp. Metastasis 20:665-674(2003)

PubMed=15289353; DOI=10.1158/0008-5472.CAN-04-0522
Tsukahara T., Nabeta Y., Kawaguchi S., Ikeda H., Sato Y., Shimozawa K., Ida K., Asanuma H., Hirohashi Y., Torigoe T., Hiraga H., Nagoya S., Wada T., Yamashita T., Sato N.
Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.
Cancer Res. 64:5442-5448(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=26320182; DOI=10.18632/oncotarget.5177
Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J., Lizardo M.M., Osborne T., Li S.Q., Luu H.H., Meltzer P., Khanna C.
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29334376; DOI=10.1038/nm.4475
Morrow J.J., Bayles I., Funnell A.P.W., Miller T.E., Saiakhova A., Lizardo M.M., Bartels C.F., Kapteijn M.Y., Hung S., Mendoza A., Dhillon G., Chee D.R., Myers J.T., Allen F., Gambarotti M., Righi A., DiFeo A., Rubin B.P., Huang A.Y., Meltzer P.S., Helman L.J., Picci P., Versteeg H.H., Stamatoyannopoulos J.A., Khanna C., Scacheri P.C.
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
Nat. Med. 24:176-185(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0427
Cell line databases/resources CCLE; HUO9_BONE
Cell_Model_Passport; SIDM00599
Cosmic-CLP; 907072
GDSC; 907072
LINCS_LDP; LCL-1423
Biological sample resources BioSample; SAMN03471626
Chemistry resources ChEMBL-Cells; CHEMBL3308748
ChEMBL-Targets; CHEMBL1075476
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM320823
GEO; GSM1669921
GEO; GSM1676303
GEO; GSM1701638
GEO; GSM1914988
GEO; GSM1914989
GEO; GSM1914990
GEO; GSM1914991
Other Wikidata; Q54896887
Polymorphism and mutation databases Cosmic; 907072
Cosmic; 931040
IARC_TP53; 21390
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number25