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Cellosaurus IGR-1 (CVCL_1303)

[Text version]

Cell line name IGR-1
Synonyms IGR 1; IGR1
Accession CVCL_1303
Resource Identification Initiative To cite this cell line use: IGR-1 (RRID:CVCL_1303)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~75-100 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for BRAF p.Val600Lys (c.1798_1799delGTinsAA) (CLS; PubMed=25056119).
Heterozygous for RAC1 p.Pro29Ser (c.85C>T) (PubMed=25056119).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.53
Native American0
East Asian, North2.53
East Asian, South0
South Asian0.58
European, North60.87
European, South35.49
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Groin lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RS51 (IGR-1rCDDP2000)CVCL_RS52 (IGR-1rDACARB40)
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP; DSMZ; PubMed=25056119; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D3S135814,17
D5S81810,11 (CLS; Cosmic-CLP; DSMZ; PubMed=25877200)
10,14 (PubMed=25056119)
D7S82010,11
D8S117910 (CLS)
10,14 (PubMed=25056119; PubMed=25877200)
D13S31713
D16S53911,13 (CLS; Cosmic-CLP; DSMZ; PubMed=25877200)
11 (PubMed=25056119)
D18S5116 (CLS)
14,16 (PubMed=25877200)
D21S1132.2
FGA23,24
Penta D10
Penta E7,11
TH017,9.3 (CLS)
9.3 (Cosmic-CLP; DSMZ; PubMed=25056119; PubMed=25877200)
TPOX8
vWA17,18 (CLS; Cosmic-CLP; DSMZ; PubMed=25877200)
18 (PubMed=25056119)

Run an STR similarity search on this cell line
Publications

PubMed=954556; DOI=10.1016/0014-2964(76)90033-5
Aubert C., Lagrange C., Rorsman H., Rosengren E.
Catechols in primary and metastatic human malignant melanoma cells in monolayer culture.
Eur. J. Cancer 12:441-445(1976)

PubMed=405430; DOI=10.1111/1523-1747.ep12496554
Foa C., Aubert C.
Cellular localization of tyrosinase in human malignant melanoma cell lines.
J. Invest. Dermatol. 68:369-378(1977)

PubMed=6929009; DOI=10.1093/jnci/64.5.1029
Aubert C., Rouge F., Galindo J.R.
Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.
J. Natl. Cancer Inst. 64:1029-1040(1980)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25056119; DOI=10.1158/0008-5472.CAN-14-1232-T
Watson I.R., Li L., Cabeceiras P.K., Mahdavi M., Gutschner T., Genovese G., Wang G., Fang Z., Tepper J.M., Stemke-Hale K., Tsai K.Y., Davies M.A., Mills G.B., Chin L.
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.
Cancer Res. 74:4845-4852(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections CLS; 300219/p483_IGR-1
CLS; 300219-SF/p11286_IGR-1
DSMZ; ACC-236
Cell line databases/resources CLDB; cl2624
CCLE; IGR1_SKIN
Cell_Model_Passport; SIDM01060
Cosmic-CLP; 907169
GDSC; 907169
LINCS_LDP; LCL-1247
Ontologies CLO; CLO_0006669
Biological sample resources BioSample; SAMN03472901
Chemistry resources ChEMBL-Cells; CHEMBL3308749
ChEMBL-Targets; CHEMBL1075479
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887157
GEO; GSM888229
GEO; GSM1669927
Other Wikidata; Q54897358
Polymorphism and mutation databases Cosmic; 907169
Cosmic; 2230115
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number24