Cellosaurus IMR-5 (CVCL_1306)

Cell line name IMR-5
Synonyms IMR 5; IMR5; IMR-05; Institute for Medical Research-5
Accession CVCL_1306
Resource Identification Initiative To cite this cell line use: IMR-5 (RRID:CVCL_1306)
Comments Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Disease Neuroblastoma (NCIt: C3270)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0346 (IMR-32)
Children: CVCL_M473 (IMR-5/75); CVCL_M472 (IMR-5/M-1)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S3179
D16S5398
D5S81811,12
D7S8209,10
TH017,9.3
TPOX11
vWA15
Publications

PubMed=6160155
Momoi M., Kennett R.H., Glick M.C.
A membrane glycoprotein from human neuroblastoma cells isolated with the use of a monoclonal antibody.
J. Biol. Chem. 255:11914-11921(1980)

PubMed=12536080; DOI=10.1016/S0304-3835(02)00581-5
Fischer M., Berthold F.
Characterization of the gene expression profile of neuroblastoma cell line IMR-5 using serial analysis of gene expression.
Cancer Lett. 190:79-87(2003)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R., Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B., Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G., Gabbert H.E., Poremba C.
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177-177(2006)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references
Cell line collections ICLC; HTL00009
Cell line databases/resources CLDB; cl5097
Cosmic-CLP; 907170
GDSC; 907170
LINCS_LDP; LCL-1984
Ontologies BTO; BTO:0005846
CLO; CLO_0006950
Chemistry resources ChEMBL-Cells; CHEMBL3308201
ChEMBL-Targets; CHEMBL2366209
Gene expression databases GEO; GSM1669935
GEO; GSM2371236
GEO; GSM2394389
Polymorphism and mutation databases Cosmic; 907170
Cosmic; 1019939
Cosmic; 1109364
Cosmic; 1161989
Cosmic; 1167417
Cosmic; 1890113