Cellosaurus IPC-298 (CVCL_1307)

Cell line name IPC-298
Synonyms IPC 298; IPC298
Accession CVCL_1307
Resource Identification Initiative To cite this cell line use: IPC-298 (RRID:CVCL_1307)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: CDKN2A p.Arg99Pro (PubMed=9354451).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D13S31711
D16S53912,14
D18S5113
D21S1129,31
D3S135818
D5S81810,11
D7S82011,12
D8S117913,15
FGA23,24
Penta D11,14
Penta E5,10
TH016,9
TPOX10,12
vWA18,22
Publications

PubMed=8325707; DOI=10.1002/ijc.2910540513
Aubert C., Rouge F., Reillaudou M., Metge P.
Establishment and characterization of human ocular melanoma cell lines.
Int. J. Cancer 54:784-792(1993)

PubMed=9354451
Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M., Gabrielli B.G., Parsons P.G., Hayward N.K.
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-251
Cell line databases/resources CLDB; cl2901
CCLE; IPC298_SKIN
Cosmic-CLP; 907171
GDSC; 907171
LINCS_LDP; LCL-1250
Ontologies BTO; BTO:0005774
CLO; CLO_0006961
EFO; EFO_0006447
Biological sample resources BioSample; SAMN03471908
Chemistry resources ChEMBL-Cells; CHEMBL3308797
ChEMBL-Targets; CHEMBL1075480
Gene expression databases GEO; GSM887163
GEO; GSM888235
GEO; GSM1669940
Polymorphism and mutation databases Cosmic; 907171
Cosmic; 928731