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Cellosaurus IST-Mes2 (CVCL_1312)

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Cell line name IST-Mes2
Synonyms IST-MES2; IST-MES-2; ISTMES2; IstMes2; Istituto Scientifico Tumori-Mesothelioma 2
Accession CVCL_1312
Resource Identification Initiative To cite this cell line use: IST-Mes2 (RRID:CVCL_1312)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: TCGA-110-CL cell line panel.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.1
East Asian, North2.01
East Asian, South0
South Asian2.87
European, North43.48
European, South51.54
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): ICLC

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812,13
D7S82010
D13S31713
D16S53911
D21S1128,29
TH019
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=10232421; DOI=10.1183/09031936.99.13352799
Orengo A.M., Spoletini L., Procopio A., Favoni R.E., De Cupis A., Ardizzoni A., Castagneto B., Ribotta M., Betta P.G., Ferrini S., Mutti L.
Establishment of four new mesothelioma cell lines: characterization by ultrastructural and immunophenotypic analysis.
Eur. Respir. J. 13:527-534(1999)

PubMed=16704740; DOI=10.1186/1471-2407-6-130
Martarelli D., Catalano A., Procopio A., Orecchia S., Libener R., Santoni G.
Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis.
BMC Cancer 6:130.1-130.7(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574-3574(2019)

Cross-references
Cell line collections ICLC; HTL01007
Cell line databases/resources CLDB; cl5544
CCLE; ISTMES2_PLEURA
Cell_Model_Passport; SIDM01554
DepMap; ACH-000331
Ontologies CLO; CLO_0006973
Biological sample resources BioSample; SAMN10988152
Chemistry resources PharmacoDB; ISTMES2_671_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887166
GEO; GSM888238
GEO; GSM1029450
GEO; GSM1029451
GEO; GSM1029452
GEO; GSM1029453
GEO; GSM1029454
GEO; GSM1029455
GEO; GSM1029456
GEO; GSM1029457
GEO; GSM1029458
GEO; GSM1029459
Other Wikidata; Q54898348
Polymorphism and mutation databases IARC_TP53; 28300
LiGeA; CCLE_183
Progenetix; CVCL_1312
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number20