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Cellosaurus IST-SL1 (CVCL_1313)

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Cell line name IST-SL1
Synonyms Istituto Scientifico Tumori-Small cell Lung 1
Accession CVCL_1313
Resource Identification Initiative To cite this cell line use: IST-SL1 (RRID:CVCL_1313)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 9884; RB1; Simple; c.2520+1G>A; ClinVar=VCV000126805; Zygosity=Homozygous; Note=Splice donor mutation (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North0.16
East Asian, South1.69
South Asian0
European, North34.83
European, South63.08
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ICLC


Run an STR similarity search on this cell line

PubMed=8795583; DOI=10.1038/bjc.1996.437
Meazza R., Marciano S., Sforzini S., Orengo A.M., Coppolecchia M., Musiani P., Ardizzoni A., Santi L., Azzarone B., Ferrini S.
Analysis of IL-2 receptor expression and of the biological effects of IL-2 gene transfection in small-cell lung cancer.
Br. J. Cancer 74:788-795(1996)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ICLC; HTL97012
Cell line databases/resources CLDB; cl2908
Cell_Model_Passport; SIDM00223
Cosmic-CLP; 753564
DepMap; ACH-002144
Ontologies CLO; CLO_0006974
Chemistry resources ChEMBL-Cells; CHEMBL3308263
ChEMBL-Targets; CHEMBL2366104
GDSC; 753564
PharmacoDB; ISTSL1_672_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669944
Other Wikidata; Q54898350
Polymorphism and mutation databases Cosmic; 753564
Cosmic; 1995457
IARC_TP53; 27558
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number27