ID   IST-SL1
AC   CVCL_1313
SY   IST SL1; ISTSL1; Istituto Scientifico Tumori-Small cell Lung 1
DR   CLO; CLO_0006974
DR   CLDB; cl2908
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   cancercelllines; CVCL_1313
DR   Cell_Model_Passport; SIDM00223
DR   ChEMBL-Cells; CHEMBL3308263
DR   ChEMBL-Targets; CHEMBL2366104
DR   Cosmic; 753564
DR   Cosmic; 1995457
DR   Cosmic-CLP; 753564
DR   DepMap; ACH-002144
DR   EGA; EGAS00001000978
DR   GDSC; 753564
DR   GEO; GSM1669944
DR   IARC_TP53; 27558
DR   ICLC; HTL97012
DR   LINCS_LDP; LCL-1868
DR   PharmacoDB; ISTSL1_672_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1313
DR   Wikidata; Q54898350
RX   PubMed=8795583;
RX   PubMed=20164919;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; c.2520+1G>A; ClinVar=VCV000126805; Zygosity=Homozygous; Note=Splice donor mutation (Cosmic-CLP; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0.24%; Native American=0%; East Asian, North=0.16%; East Asian, South=1.69%; South Asian=0%; European, North=34.83%; European, South=63.08% (PubMed=30894373).
CC   Derived from site: Metastatic; Supraclavicular lymph node; UBERON=UBERON_0035279.
ST   Source(s): Cosmic-CLP; ICLC
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8
ST   D16S539: 10
ST   D21S11: 29,30
ST   D5S818: 13
ST   D7S820: 8,11
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 15,17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   60Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 34
//
RX   PubMed=8795583; DOI=10.1038/bjc.1996.437;
RA   Meazza R., Marciano S., Sforzini S., Orengo A.M., Coppolecchia M.,
RA   Musiani P., Ardizzoni A., Santi L., Azzarone B., Ferrini S.;
RT   "Analysis of IL-2 receptor expression and of the biological effects of
RT   IL-2 gene transfection in small-cell lung cancer.";
RL   Br. J. Cancer 74:788-795(1996).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//