Cell line name | J.RT3-T3.5 | ||||||||||||||||||
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Synonyms | J.RT3/T3.5; J-RT3-T3-5; JRT3-T3.5; JRT3T3.5; JRT3T35; Jurkat RT3-T3.5; Jurkat/RT3-T3.5 | ||||||||||||||||||
Accession | CVCL_1316 | ||||||||||||||||||
Secondary accession | CVCL_9725 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: J.RT3-T3.5 (RRID:CVCL_1316) | ||||||||||||||||||
Comments | Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981). Characteristics: Does not express the beta chain of the T cell antigen receptor. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Peripheral blood. | ||||||||||||||||||
Sequence variations | Gene fusion; FAM133B-CDK6 (PubMed=23637631).Heterozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (from parent cell line).Heterozygous for BAX p.Glu41Glyfs*33 (c.121dupG) (ClinVar=VCV000009511) (from parent cell line).Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) (from parent cell line).Heterozygous for INPP5D c.1097+1065_1097+1112del47 (from parent cell line).Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (ClinVar=VCV000090903) (from parent cell line).Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (ClinVar=VCV000089363) (from parent cell line).Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (from parent cell line). | ||||||||||||||||||
Disease | Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Parent: CVCL_0367 (Jurkat E6.1) Children:
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Sex of cell | Male | ||||||||||||||||||
Age at sampling | 14Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): ATCC Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | PubMed=6208306; DOI=10.1084/jem.160.5.1284 PubMed=20164919; DOI=10.1038/nature08768 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=23637631; DOI=10.1371/journal.pgen.1003464 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections | ATCC; TIB-153 | ||||||||||||||||||
Cell line databases/resources | Cell_Model_Passport; SIDM01263
IGRhCellID; JRT3T35 LINCS_LDP; LCL-1014 | ||||||||||||||||||
Ontologies | CLO; CLO_0006984
EFO; EFO_0002213 | ||||||||||||||||||
Biological sample resources | BioSample; SAMN03471939 | ||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308326
ChEMBL-Targets; CHEMBL2366219 GDSC; 907391 PharmacoDB; JRT3T35_674_2019 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783 ArrayExpress; E-MTAB-3610 GEO; GSM1669963 | ||||||||||||||||||
Other | Wikidata; Q54898432 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 683538
Cosmic; 907391 Cosmic; 1151780 Progenetix; CVCL_1316 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||
Version number | 27 |