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Cellosaurus J.RT3-T3.5 (CVCL_1316)

[Text version]

Cell line name J.RT3-T3.5
Synonyms J.RT3/T3.5; J-RT3-T3-5; JRT3-T3.5; JRT3T3.5; JRT3T35; Jurkat RT3-T3.5; Jurkat/RT3-T3.5
Accession CVCL_1316
Secondary accession CVCL_9725
Resource Identification Initiative To cite this cell line use: J.RT3-T3.5 (RRID:CVCL_1316)
Comments Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Characteristics: Does not express the beta chain of the T cell antigen receptor.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Gene fusion; HGNC; 1777; CDK6 + HGNC; 28629; FAM133B; Name(s)=FAM133B-CDK6 (PubMed=23637631).
Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_GX97 (CH7C17)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S81810
D7S8208,10
D13S3178,12
D16S53911
TH016,9.3
TPOX8,10
vWA18

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Publications

PubMed=6208306; DOI=10.1084/jem.160.5.1284
Weiss A., Stobo J.D.
Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.
J. Exp. Med. 160:1284-1299(1984)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23637631; DOI=10.1371/journal.pgen.1003464
Giacomini C.P., Sun S., Varma S., Shain A.H., Giacomini M.M., Balagtas J., Sweeney R.T., Lai E., Del Vecchio C.A., Forster A.D., Clarke N., Montgomery K.D., Zhu S., Wong A.J., van de Rijn M., West R.B., Pollack J.R.
Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.
PLoS Genet. 9:E1003464-E1003464(2013)

Cross-references
Cell line collections ATCC; TIB-153
Cell line databases/resources Cell_Model_Passport; SIDM01263
IGRhCellID; JRT3T35
LINCS_LDP; LCL-1014
Ontologies CLO; CLO_0006984
EFO; EFO_0002213
Biological sample resources BioSample; SAMN03471939
Chemistry resources ChEMBL-Cells; CHEMBL3308326
ChEMBL-Targets; CHEMBL2366219
GDSC; 907391
PharmacoDB; JRT3T35_674_2019
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669963
Other Wikidata; Q54898432
Polymorphism and mutation databases Cosmic; 683538
Cosmic; 907391
Cosmic; 1151780
Progenetix; CVCL_1316
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number28