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Cellosaurus J.RT3-T3.5 (CVCL_1316)

[Text version]

Cell line name J.RT3-T3.5
Synonyms J.RT3/T3.5; J-RT3-T3-5; JRT3-T3.5; JRT3T3.5; JRT3T35; Jurkat RT3-T3.5; Jurkat/RT3-T3.5
Accession CVCL_1316
Secondary accession CVCL_9725
Resource Identification Initiative To cite this cell line use: J.RT3-T3.5 (RRID:CVCL_1316)
Comments Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Characteristics: Does not express the beta chain of the T cell antigen receptor.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_GX97 (CH7C17)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S81810
D7S8208,10
D13S3178,12
D16S53911
TH016,9.3
TPOX8,10
vWA18
Publications

PubMed=6208306; DOI=10.1084/jem.160.5.1284
Weiss A., Stobo J.D.
Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.
J. Exp. Med. 160:1284-1299(1984)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections ATCC; TIB-153
Cell line databases/resources Cell_Model_Passport; SIDM01263
GDSC; 907391
IGRhCellID; JRT3T35
LINCS_LDP; LCL-1014
Ontologies CLO; CLO_0006984
EFO; EFO_0002213
Biological sample resources BioSample; SAMN03471939
Chemistry resources ChEMBL-Cells; CHEMBL3308326
ChEMBL-Targets; CHEMBL2366219
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669963
Other Wikidata; Q54898432
Polymorphism and mutation databases Cosmic; 683538
Cosmic; 907391
Cosmic; 1151780