Cellosaurus KO52 (CVCL_1321)

Cell line name KO52
Synonyms K052
Accession CVCL_1321
Secondary accession CVCL_8455
Resource Identification Initiative To cite this cell line use: KO52 (RRID:CVCL_1321)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~48 hours (PubMed=7693050).
Microsatellite instability: Instable (MSI-low) (Sanger).
Sequence variation: NRAS p.Gly13Arg (PubMed=7693050).
Sequence variation: TP53 p.Arg248Trp (PubMed=7693050).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Disease Adult acute myeloid leukemia (NCIt: C9154)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S3178,12
D16S5399,11
D5S81811
D7S8209,10
TH016,7
TPOX8
vWA16
Publications

PubMed=7693050
Abo J., Inokuchi K., Dan K., Nomura T.
p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia.
Blood 82:2829-2836(1993)

PubMed=10637496
Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H., Uphoff C.C.
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Leukemia 14:198-206(2000)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0123
JCRB; NIHS0164 - Discontinued
Cell line databases/resources CCLE; KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 1330932
GDSC; 907284
LINCS_LDP; LCL-1080
Biological sample resources BioSample; SAMN03470799
Chemistry resources ChEMBL-Cells; CHEMBL3308169
ChEMBL-Targets; CHEMBL2366354
Gene expression databases GEO; GSM827240
GEO; GSM887233
GEO; GSM888307
GEO; GSM1669969
GEO; GSM1669998
Polymorphism and mutation databases Cosmic; 749073
Cosmic; 907284
Cosmic; 2131543
Cosmic; 2306214