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Cellosaurus Karpas-45 (CVCL_1326)

Cell line name Karpas-45
Synonyms KARPAS-45; Karpas 45; KARPAS 45; KARPAS45; K45; T-45; T45
Accession CVCL_1326
Resource Identification Initiative To cite this cell line use: Karpas-45 (RRID:CVCL_1326)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 50-100 hours (ECACC).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX,Y
CSF1PO11,14
D13S3179,14
D16S5399,13
D5S81811,12
D7S8208,11
TH019
TPOX8
vWA14,18
Publications

DOI=10.1016/0145-2126(77)90063-7
Karpas A., Hayhoe F.G.J., Greenberger J.S., Barker C.R., Cawley J.C., Lowenthal R.M., Moloney W.C.
The establishment and cytological, cytochemical and immunological characterisation of human haemic cell lines: evidence for heterogeneity.
Leuk. Res. 1:35-49(1977)

PubMed=3264071; DOI=10.1073/pnas.85.23.9229
Karpas A., Fleet G.W.J., Dwek R.A., Petursson S., Namgoong S.K., Ramsden N.G., Jacob G.S., Rademacher T.W.
Aminosugar derivatives as potential anti-human immunodeficiency virus agents.
Proc. Natl. Acad. Sci. U.S.A. 85:9229-9233(1988)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Kalender Atak Z., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-105 - Discontinued
ECACC; 06072602
NCBI_Iran; C180
Cell line databases/resources CLDB; cl35
CCLE; KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 907272
GDSC; 907272
LINCS_LDP; LCL-1015
Ontologies CLO; CLO_0007067
Biological sample resources BioSample; SAMN03473409
Chemistry resources ChEMBL-Cells; CHEMBL3308305
ChEMBL-Targets; CHEMBL2366305
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669977
Other Wikidata; Q54899501
Polymorphism and mutation databases Cosmic; 907272
Cosmic; 913413
Cosmic; 1012075
Cosmic; 1151781
Cosmic; 1175130
Cosmic; 1191704
Cosmic; 1281370
Cosmic; 1330505
Cosmic; 1524799
Cosmic; 1664523
Cosmic; 1760525
Cosmic; 2165714
Cosmic; 2391812
Cosmic; 2602917