Cellosaurus cell line Karpas-45 (CVCL_1326)

• Gene fusion; HGNC; 7139; FOXO4 + HGNC; 7132; KMT2A; Name(s)=KMT2A-FOXO4, MLL-MLLT7; MLL-AFX1 (PubMed=14671638; PubMed=15843827).
  
• Mutation; HGNC; 583; APC; Simple; p.Val2194Ala (c.6581T>C); ClinVar=VCV000565658; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (DepMap).
  
• Mutation; HGNC; 3430; ERBB2; Simple; p.Ala586Gly (c.1757C>G); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 3495; ETV6; Simple; p.His328Tyr (c.982C>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 3689; FGFR2; Simple; p.Met584Arg (c.1751T>G) (p.Met585Arg, c.1754T>G); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 6307; KDR; Simple; p.Arg962His (c.2885G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 6342; KIT; Simple; p.Asp131Asn (c.391G>A); ClinVar=VCV000409719; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 7029; MET; Simple; p.Ala48Thr (c.142G>A); ClinVar=VCV000454188; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 7029; MET; Simple; p.Glu157Gly (c.470A>G); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 7325; MSH2; Simple; p.Gly221Val (c.662G>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (PubMed=15472075).
  
• Mutation; HGNC; 7881; NOTCH1; Simple; p.Asp1852Asn (c.5554G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 7881; NOTCH1; Simple; p.Val2045Ile (c.6133G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 8804; PDGFRB; Simple; p.His277Gln (c.831C>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 9967; RET; Simple; p.Asn879Ser (c.2636A>G); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 11103; SMARCB1; Simple; p.Asn288Lys (c.864C>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP; DepMap).
  
• Mutation; HGNC; 12796; WT1; Simple; p.Arg394Gln (c.1181G>A) (p.Arg467Gln, c.1400G>A); ClinVar=VCV000419332; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP).
  

DOI=10.1016/0145-2126(77)90063-7
Karpas A., Hayhoe F.G.J., Greenberger J.S., Barker C.R., Cawley J.C., Lowenthal R.M., Moloney W.C.
The establishment and cytological, cytochemical and immunological characterisation of human haemic cell lines: evidence for heterogeneity.
Leuk. Res. 1:35-49(1977)

DOI=10.1007/978-1-4613-2823-0_29
Karpas A.
Viruses and human leukemia in vitro.
(In) Human leukemia. Cytochemical and ultrastructural techniques in diagnosis and research. Developments in Oncology, Vol. 14; Polliack A. (eds.); pp.495-526; Martinus Nijhoff Publishing; Boston (1984)

PubMed=3264071; DOI=10.1073/pnas.85.23.9229
Karpas A., Fleet G.W.J., Dwek R.A., Petursson S., Namgoong S.K., Ramsden N.G., Jacob G.S., Rademacher T.W.
Aminosugar derivatives as potential anti-human immunodeficiency virus agents.
Proc. Natl. Acad. Sci. U.S.A. 85:9229-9233(1988)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Burger R., Hansen-Hagge T.E., Drexler H.G., Gramatzki M.
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15472075; DOI=10.1126/science.1102160
Weng A.P., Ferrando A.A., Lee W., Morris J.P. IV, Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., Aster J.C.
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Sandberg Y., Verhaaf B., van Gastel-Mol E.J., Wolvers-Tettero I.L.M., de Vos J., MacLeod R.A.F., Noordzij J.G., Dik W.A., van Dongen J.J.M., Langerak A.W.
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22675565; DOI=10.1371/journal.pone.0038463
Atak Z.K., De Keersmaecker K., Gianfelici V., Geerdens E., Vandepoel R., Pauwels D., Porcu M., Lahortiga I., Brys V., Dirks W.G., Quentmeier H., Cloos J., Cuppens H., Uyttebroeck A., Vandenberghe P., Cools J., Aerts S.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:E38463-E38463(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)