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Cellosaurus KINGS-1 (CVCL_1328)

[Text version]

Cell line name KINGS-1
Synonyms Kings-1; KINGS1
Accession CVCL_1328
Resource Identification Initiative To cite this cell line use: KINGS-1 (RRID:CVCL_1328)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: Indicated to be from a 67 year old male patient in CelloPub=CLPUB00151 and from a 72 year old in JCRB IFO50435.
Derived from sampling site: Brain.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Heterozygous (Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North73.94
East Asian, South26.06
South Asian0
European, North0
European, South0
Disease Anaplastic astrocytoma (NCIt: C9477)
Anaplastic astrocytoma (ORDO: Orphanet_251589)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200

Penta D10,13
Penta E16,25

Run an STR similarity search on this cell line

Iryo O.
Establishment and characterization of a human glioma cell-line (KINGS-1) carrying leukocytes differentiation antigens.
J. Kurume Med. Assoc. 51:304-316(1988)

PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x
Saigusa K., Hashimoto N., Tsuda H., Yokoi S., Maruno M., Yoshimine T., Aoyagi M., Ohno K., Imoto I., Inazawa J.
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Cancer Sci. 96:676-683(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections JCRB; IFO50435
Cell line databases/resources CCLE; KINGS1_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM00612
CGH-DB; 143-1
Cosmic-CLP; 907279
DepMap; ACH-002257
Biological sample resources BioSample; SAMN03470889
Chemistry resources ChEMBL-Cells; CHEMBL3308264
ChEMBL-Targets; CHEMBL2366229
GDSC; 907279
PharmacoDB; KINGS1_749_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669986
Other Wikidata; Q54899934
Polymorphism and mutation databases Cosmic; 907279
Cosmic; 2367531
IARC_TP53; 21432
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number28