Home  |  Contact

Cellosaurus KMOE-2 (CVCL_1332)

[Text version]

Cell line name KMOE-2
Synonyms KMOE2; Kmoe2
Accession CVCL_1332
Resource Identification Initiative To cite this cell line use: KMOE-2 (RRID:CVCL_1332)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 24.2 hours (PubMed=6949905); ~40-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Val272Met (c.814G>A); ClinVar=VCV000185814; Zygosity=Homozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.02
East Asian, North78.12
East Asian, South19.8
South Asian1.43
European, North0.23
European, South0
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UF71 (KMOE-2/05)
Originate from same individual CVCL_W022 ! KMOE-1
Sex of cell Female
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ


Run an STR similarity search on this cell line

PubMed=6949905; DOI=10.1007/BF00410534
Okano H., Okamura J., Yagawa K., Tasaka H., Motomura S.
Human erythroid cell lines derived from a patient with acute erythremia.
J. Cancer Res. Clin. Oncol. 102:49-55(1981)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections DSMZ; ACC-37
Cell line databases/resources CLDB; cl3034
Cell_Model_Passport; SIDM01019
Cosmic-CLP; 907280
DepMap; ACH-002258
Ontologies CLO; CLO_0007114
Biological sample resources BioSample; SAMN03473322
Chemistry resources ChEMBL-Cells; CHEMBL3308236
ChEMBL-Targets; CHEMBL2366347
GDSC; 907280
PharmacoDB; KMOE2_757_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1446748
GEO; GSM1669991
Other Wikidata; Q54900132
Polymorphism and mutation databases Cosmic; 787445
Cosmic; 907280
Cosmic; 975262
Cosmic; 1012079
Cosmic; 1465969
Cosmic; 2131542
Cosmic; 2306213
IARC_TP53; 21434
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number31