Cellosaurus KOSC-2 (CVCL_1337)

Cell line name KOSC-2
Synonyms KOSC2; KOSC-2 cl3-43
Accession CVCL_1337
Resource Identification Initiative To cite this cell line use: KOSC-2 (RRID:CVCL_1337)
Comments Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Disease Head and neck squamous cell carcinoma (NCIt: C34447)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO12
D13S31711
D16S5399,12
D5S8189
D7S82010,11
TH016,7
TPOX8
vWA15,17
Publications

PubMed=8314315; DOI=10.1002/ijc.2910560226
Inagaki T., Matsuwari S., Takahashi R., Shimada K.-K., Fujie K., Maeda S.
Establishment of human oral-cancer cell lines (KOSC-2 and -3) carrying p53 and c-myc abnormalities by geneticin treatment.
Int. J. Cancer 56:301-308(1994)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0126.1
Cell line databases/resources CGH-DB; 371-2
Cosmic-CLP; 753570
GDSC; 753570
LINCS_LDP; LCL-1227
Ontologies BTO; BTO:0005968
Biological sample resources BioSample; SAMN03470801
Chemistry resources ChEMBL-Cells; CHEMBL3308750
ChEMBL-Targets; CHEMBL1075481
Gene expression databases GEO; GSM827195
GEO; GSM1670001
Polymorphism and mutation databases Cosmic; 753570