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Cellosaurus KOSC-2 (CVCL_1337)

[Text version]

Cell line name KOSC-2
Synonyms KOSC2; KOSC-2 cl3-43; Kobe University Oral Squamous Cell Culture-2
Accession CVCL_1337
Resource Identification Initiative To cite this cell line use: KOSC-2 (RRID:CVCL_1337)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 18.7 hours (PubMed=8314315).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.44
Native American0
East Asian, North72.8
East Asian, South22.55
South Asian0
European, North0
European, South3.2
Disease Head and neck squamous cell carcinoma (NCIt: C34447)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO12
D5S8189
D7S82010,11
D13S31711
D16S5399,12
TH016,7
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=8314315; DOI=10.1002/ijc.2910560226
Inagaki T., Matsuwari S., Takahashi R., Shimada K.-K., Fujie K., Maeda S.
Establishment of human oral-cancer cell lines (KOSC-2 and -3) carrying p53 and c-myc abnormalities by geneticin treatment.
Int. J. Cancer 56:301-308(1994)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0126.1
Cell line databases/resources CCLE; KOSC2_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00603
CGH-DB; 371-2
Cosmic-CLP; 753570
DepMap; ACH-002260
GDSC; 753570
LINCS_LDP; LCL-1227
Ontologies BTO; BTO:0005968
Biological sample resources BioSample; SAMN03470801
Chemistry resources ChEMBL-Cells; CHEMBL3308750
ChEMBL-Targets; CHEMBL1075481
PharmacoDB; KOSC2_780_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827195
GEO; GSM1670001
Other Wikidata; Q54900341
Polymorphism and mutation databases Cosmic; 753570
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number25