Cellosaurus KP-4 (CVCL_1338)

Cell line name KP-4
Synonyms KP 4; KP4
Accession CVCL_1338
Resource Identification Initiative To cite this cell line use: KP-4 (RRID:CVCL_1338)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 27 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Metabolome analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Pancreatic carcinoma (NCIt: C3850)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_8727 (KP-4-1); CVCL_8728 (KP-4-2); CVCL_8729 (KP-4-3); CVCL_Y142 (KP-4-4)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200; RCB

Markers:
AmelogeninX
CSF1PO10,12
D13S31710
D16S53910
D18S5115
D21S1129,30
D3S135815
D5S81810,12
D7S82010,11
D8S117911,13
FGA21,25
Penta D9,14
Penta E12
TH019,10
TPOX9,11 (Cosmic-CLP; JCRB)
9 (PubMed=25877200)
vWA14
Web pages http://colt.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=KP-4
Publications

PubMed=21559554; DOI=10.3892/ijo.5.1.33
Nishi Y., Haji M., Takayanagi R., Iguchi H., Shimazoe T., Hirata J., Nawata H.
Establishment and characterization of PTHrP-producing human pancreatic-cancer cell-line.
Int. J. Oncol. 5:33-39(1994)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112
Daemen A., Peterson D., Sahu N., McCord R., Du X., Liu B., Kowanetz K., Hong R., Moffat J., Gao M., Boudreau A., Mroue R., Corson L., O'Brien T., Qing J., Sampath D., Merchant M., Yauch R., Manning G., Settleman J., Hatzivassiliou G., Evangelista M.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0182
RCB; RCB1005
Cell line databases/resources CCLE; KP4_PANCREAS
CGH-DB; 9373-4
Cosmic-CLP; 753572
GDSC; 753572
LINCS_LDP; LCL-1725
Ontologies CLO; CLO_0050109
EFO; EFO_0006623
Biological sample resources BioSample; SAMN03472375
BioSample; SAMN03472831
Chemistry resources ChEMBL-Cells; CHEMBL3308751
ChEMBL-Targets; CHEMBL1075482
Gene expression databases GEO; GSM827214
GEO; GSM887237
GEO; GSM888311
GEO; GSM1374602
GEO; GSM1670004
Polymorphism and mutation databases Cosmic; 753572