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Cellosaurus KP-N-RT-BM-1 (CVCL_1339)

[Text version]

Cell line name KP-N-RT-BM-1
Synonyms KPNRTBM1; RT-BM-1; RT-BM 1; RTBM1; KP-N-RT-BM; KP-N-RTBM; RT-BM; KP-N-RT; Kyoto Pediatrics-Neuroblastoma-RT-Bone Marrow
Accession CVCL_1339
Resource Identification Initiative To cite this cell line use: KP-N-RT-BM-1 (RRID:CVCL_1339)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.43
Native American0.27
East Asian, North72.99
East Asian, South24.04
South Asian0
European, North0
European, South2.27
Disease Adrenal gland neuroblastoma (NCIt: C4827)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_9512 (KP-N-RT-RT-BMV-C6)
Originate from same individual CVCL_9511 ! KP-N-RT-LN
Sex of cell Female
Age at sampling 1Y2M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133820
D3S135815,17
D5S81810,13
D7S82010,11
D8S117912,13
D13S3179,12
D16S53910,12
D18S5115,17
D19S43313
D21S1130,31.2
FGA20,21
Penta D9,12
Penta E12,16
TH016,7
TPOX8
vWA17,20

Run an STR similarity search on this cell line
Publications

PubMed=3731124
Sugimoto T., Sawada T., Matsumura T., Kemshead J.T., Ishii T., Horii Y., Morioka H., Morita M., Reynolds C.P.
Identical expression of cell surface membrane antigens on two parent and eighteen cloned cell lines derived from two different neuroblastoma metastases of the same patient.
Cancer Res. 46:4765-4769(1986)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

PubMed=11129446; DOI=10.1097/00019606-200012000-00007
Sugimoto T., Mine H., Horii Y., Takahashi K., Nagai R., Morishita R., Komada M., Asada Y., Sawada T.
Neuroblastoma cell lines showing smooth muscle cell phenotypes.
Diagn. Mol. Pathol. 9:221-228(2000)

PubMed=12702577
Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A., Naylor T., Cole K., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23268333; DOI=10.1016/j.canlet.2012.12.011
Sugimoto T., Gotoh T., Yagyu S., Kuroda H., Iehara T., Hosoi H., Ohta S., Ohira M., Nakagawara A.
A MYCN-amplified cell line derived from a long-term event-free survivor among our sixteen established neuroblastoma cell lines.
Cancer Lett. 331:115-121(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

CLPUB00582
Sugimoto T., Kuroda H., Yagyu S., Gotoh T., Osone S., Tamura T., Iehara T., Hosoi H.
Cellular and molecular characteristics of established neuroblastoma cell lines.
J. Cancer Res. Therap. Oncol. 7:201.1-201.15(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; IFO50432
Cell line databases/resources CCLE; KPNRTBM1_AUTONOMIC_GANGLIA
Cell_Model_Passport; SIDM00557
CGH-DB; 69-1
CGH-DB; 9079-4
Cosmic-CLP; 924189
DepMap; ACH-000345
Biological sample resources BioSample; SAMN03470963
BioSample; SAMN10987720
Chemistry resources ChEMBL-Cells; CHEMBL3308339
ChEMBL-Targets; CHEMBL2366107
GDSC; 924189
PharmacoDB; KPNRTBM1_786_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
GEO; GSM887239
GEO; GSM888313
GEO; GSM1670005
Other Wikidata; Q54900391
Polymorphism and mutation databases Cosmic; 848926
Cosmic; 924189
LiGeA; CCLE_682
Progenetix; CVCL_1339
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number26