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Cellosaurus KP-N-YS (CVCL_1342)

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Cell line name KP-N-YS
Synonyms KPNYS
Accession CVCL_1342
Resource Identification Initiative To cite this cell line use: KP-N-YS (RRID:CVCL_1342)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Cys135Phe (c.404G>T) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.29
East Asian, North74.96
East Asian, South23.74
South Asian0
European, North0
European, South0
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_Y132 (KP-N-YS1n)CVCL_Y133 (KP-N-YS2s)
Sex of cell Male
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP


Run an STR similarity search on this cell line

Yagi M., Sugimoto T., Mine H., Horii Y., Matsumura T., Sawada T., Abe T., Sano K., Goshi J., Takahashi K.
Basic calponin expressing human neuroblastoma cell line of KP-N-YS.
Hum. Cell 11:231-238(1998)

PubMed=11129446; DOI=10.1097/00019606-200012000-00007
Sugimoto T., Mine H., Horii Y., Takahashi K., Nagai R., Morishita R., Komada M., Asada Y., Sawada T.
Neuroblastoma cell lines showing smooth muscle cell phenotypes.
Diagn. Mol. Pathol. 9:221-228(2000)

Saito-Ohara F., Imoto I., Inoue J., Hosoi H., Nakagawara A., Sugimoto T., Inazawa J.
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23268333; DOI=10.1016/j.canlet.2012.12.011
Sugimoto T., Gotoh T., Yagyu S., Kuroda H., Iehara T., Hosoi H., Ohta S., Ohira M., Nakagawara A.
A MYCN-amplified cell line derived from a long-term event-free survivor among our sixteen established neuroblastoma cell lines.
Cancer Lett. 331:115-121(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line databases/resources CCLE; KPNYS_AUTONOMIC_GANGLIA
Cell_Model_Passport; SIDM00157
CGH-DB; 82-1
CGH-DB; 9083-4
Cosmic-CLP; 946363
DepMap; ACH-002261
Chemistry resources ChEMBL-Cells; CHEMBL3308266
ChEMBL-Targets; CHEMBL2366065
GDSC; 946363
PharmacoDB; KPNYS_789_2019
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM1670008
Other Wikidata; Q54900406
Polymorphism and mutation databases Cosmic; 946363
IARC_TP53; 27174
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number25