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Cellosaurus KU-19-19 (CVCL_1344)

[Text version]

Cell line name KU-19-19
Synonyms KU 19-19; KU19-19; KU1919; Keio University-19-19
Accession CVCL_1344
Resource Identification Initiative To cite this cell line use: KU-19-19 (RRID:CVCL_1344)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~48 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations AKT1 p.Glu17Lys (c.49G>A) (ClinVar=VCV000013983) (PubMed=19802009).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North77.87
East Asian, South21.55
South Asian0
European, North0
European, South0.57
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S82010,12
D13S31711
D16S53910,12
TH017,8
TPOX8,11
vWA14,15

Run an STR similarity search on this cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=KU-19-19
Publications

PubMed=7542171
Tachibana M., Miyakawa A., Tazaki H., Nakamura K., Kubo A., Hata J.-I., Nishi T., Amano Y.
Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor.
Cancer Res. 55:3438-3443(1995)

PubMed=9464244; DOI=10.1006/bbrc.1997.8002
Steube K.G., Meyer C., Tachibana M., Murai M., Drexler H.G.
Bladder carcinoma cell line KU-19-19-derived cytokines support proliferation of growth factor-dependent hematopoietic cell lines: modulation by phorbol ester, interferon-gamma and interleukin-1 beta.
Biochem. Biophys. Res. Commun. 242:497-501(1998)

PubMed=10022529; DOI=10.1089/10430349950019174
Sumitomo M., Tachibana M., Ozu C., Asakura H., Murai M., Hayakawa M., Nakamura H., Takayanagi A., Shimizu N.
Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression.
Hum. Gene Ther. 10:37-47(1999)

PubMed=10496353; DOI=10.1038/sj.bjc.6690688
Sumitomo M., Tachibana M., Murai M., Hayakawa M., Nakamura H., Takayanagi A., Shimizu N.
Overexpression of IL-1ra gene up-regulates interleukin-1beta converting enzyme (ICE) gene expression: possible mechanism underlying IL-1beta-resistance of cancer cells.
Br. J. Cancer 81:277-286(1999)

PubMed=19802009; DOI=10.1038/onc.2009.315
Askham J.M., Platt F.M., Chambers P.A., Snowden H., Taylor C.F., Knowles M.A.
AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.
Oncogene 29:150-155(2010)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24367658; DOI=10.1371/journal.pone.0084411
Ross R.L., Burns J.E., Taylor C.F., Mellor P., Anderson D.H., Knowles M.A.
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
PLoS ONE 8:E84411-E84411(2013)

PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057
Hurst C.D., Platt F.M., Knowles M.A.
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
Eur. Urol. 65:367-369(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29732388; DOI=10.3233/BLC-180167
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections DSMZ; ACC-395
Cell line databases/resources CCLE; KU1919_URINARY_TRACT
Cell_Model_Passport; SIDM01033
Cosmic-CLP; 907312
DepMap; ACH-000486
LINCS_LDP; LCL-1715
Ontologies CLO; CLO_0007123
Biological sample resources BioSample; SAMN03473576
BioSample; SAMN10988557
ENCODE; ENCBS304FRD
ENCODE; ENCBS497ZHB
Chemistry resources ChEMBL-Cells; CHEMBL3308111
ChEMBL-Targets; CHEMBL1075483
GDSC; 907312
PharmacoDB; KU1919_794_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887243
GEO; GSM888317
GEO; GSM1374605
GEO; GSM1670010
Other Wikidata; Q54900670
Polymorphism and mutation databases Cosmic; 907312
Cosmic; 1046693
Cosmic; 1285122
Cosmic; 1286001
Cosmic; 2050448
Cosmic; 2057453
Cosmic; 2444234
Cosmic; 2686100
LiGeA; CCLE_760
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number29