Cellosaurus KU-19-19 (CVCL_1344)

Cell line name KU-19-19
Synonyms KU 19-19, KU19-19; KU1919; Keio University-19-19
Accession CVCL_1344
Resource Identification Initiative To cite this cell line use: KU-19-19 (RRID:CVCL_1344)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~48 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO9,10
D13S31711
D16S53910,12
D5S81811,12
D7S82010,12
TH017,8
TPOX8,11
vWA14,15
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=KU-19-19
Publications

PubMed=7542171
Tachibana M., Miyakawa A., Tazaki H., Nakamura K., Kubo A., Hata J., Nishi T., Amano Y.
Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor.
Cancer Res. 55:3438-3443(1995)

PubMed=9464244; DOI=10.1006/bbrc.1997.8002
Steube K.G., Meyer C., Tachibana M., Murai M., Drexler H.G.
Bladder carcinoma cell line KU-19-19-derived cytokines support proliferation of growth factor-dependent hematopoietic cell lines: modulation by phorbol ester, interferon-gamma and interleukin-1 beta.
Biochem. Biophys. Res. Commun. 242:497-501(1998)

PubMed=10022529; DOI=10.1089/10430349950019174
Sumitomo M., Tachibana M., Ozu C., Asakura H., Murai M., Hayakawa M., Nakamura H., Takayanagi A., Shimizu N.
Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression.
Hum. Gene Ther. 10:37-47(1999)

PubMed=10496353; DOI=10.1038/sj.bjc.6690688
Sumitomo M., Tachibana M., Murai M., Hayakawa M., Nakamura H., Takayanagi A., Shimizu N.
Overexpression of IL-1ra gene up-regulates interleukin-1beta converting enzyme (ICE) gene expression: possible mechanism underlying IL-1beta-resistance of cancer cells.
Br. J. Cancer 81:277-286(1999)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24367658; DOI=10.1371/journal.pone.0084411
Ross R.L., Burns J.E., Taylor C.F., Mellor P., Anderson D.H., Knowles M.A.
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
PLoS ONE 8:E84411-E84411(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-395
Cell line databases/resources CCLE; KU1919_URINARY_TRACT
Cosmic-CLP; 907312
GDSC; 907312
LINCS_LDP; LCL-1715
Ontologies CLO; CLO_0007123
Biological sample resources BioSample; SAMN03473576
Chemistry resources ChEMBL-Cells; CHEMBL3308111
ChEMBL-Targets; CHEMBL1075483
Gene expression databases GEO; GSM887243
GEO; GSM888317
GEO; GSM1374605
GEO; GSM1670010
Polymorphism and mutation databases Cosmic; 907312
Cosmic; 1046693
Cosmic; 1285122
Cosmic; 1286001
Cosmic; 2050448
Cosmic; 2057453
Cosmic; 2444234