ID   KU-19-19
AC   CVCL_1344
SY   KU 19-19; KU19-19; KU1919; Keio University-19-19
DR   CLO; CLO_0007123
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 608
DR   BioSample; SAMN03473576
DR   BioSample; SAMN10988557
DR   cancercelllines; CVCL_1344
DR   Cell_Model_Passport; SIDM01033
DR   ChEMBL-Cells; CHEMBL3308111
DR   ChEMBL-Targets; CHEMBL1075483
DR   Cosmic; 907312
DR   Cosmic; 1046693
DR   Cosmic; 1285122
DR   Cosmic; 1286001
DR   Cosmic; 2050448
DR   Cosmic; 2057453
DR   Cosmic; 2444234
DR   Cosmic; 2686100
DR   Cosmic-CLP; 907312
DR   DepMap; ACH-000486
DR   DSMZ; ACC-395
DR   DSMZCellDive; ACC-395
DR   EGA; EGAS00001000978
DR   ENCODE; ENCBS304FRD
DR   ENCODE; ENCBS497ZHB
DR   GDSC; 907312
DR   GEO; GSM887243
DR   GEO; GSM888317
DR   GEO; GSM1374605
DR   GEO; GSM1670010
DR   IARC_TP53; 21445
DR   LiGeA; CCLE_760
DR   LINCS_LDP; LCL-1715
DR   PharmacoDB; KU1919_794_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1344
DR   PubChem_Cell_line; CVCL_1344
DR   Wikidata; Q54900670
RX   PubMed=7542171;
RX   PubMed=9464244;
RX   PubMed=10022529;
RX   PubMed=10496353;
RX   PubMed=19802009;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=24035680;
RX   PubMed=24367658;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=29732388;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=KU-19-19
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: ~48 hours (DSMZ=ACC-395).
CC   HLA typing: A*31:01,33:03; B*15:01,37:01; C*03:03,06:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Unspecified (PubMed=19802009).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=77.87%; East Asian, South=21.55%; South Asian=0%; European, North=0%; European, South=0.57% (PubMed=30894373).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
ST   Source(s): Cosmic-CLP; DSMZ
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 11
ST   D16S539: 10,12
ST   D18S51: 17,20
ST   D19S433: 13,15
ST   D21S11: 30,32
ST   D2S1338: 19
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   D8S1179: 10,13
ST   FGA: 22
ST   Penta D: 13
ST   Penta E: 10,15
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 14,15
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   76Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 39
//
RX   PubMed=7542171;
RA   Tachibana M., Miyakawa A., Tazaki H., Nakamura K., Kubo A., Hata J.-i.,
RA   Nishi T., Amano Y.;
RT   "Autocrine growth of transitional cell carcinoma of the bladder
RT   induced by granulocyte-colony stimulating factor.";
RL   Cancer Res. 55:3438-3443(1995).
//
RX   PubMed=9464244; DOI=10.1006/bbrc.1997.8002;
RA   Steube K.G., Meyer C., Tachibana M., Murai M., Drexler H.G.;
RT   "Bladder carcinoma cell line KU-19-19-derived cytokines support
RT   proliferation of growth factor-dependent hematopoietic cell lines:
RT   modulation by phorbol ester, interferon-gamma and interleukin-1
RT   beta.";
RL   Biochem. Biophys. Res. Commun. 242:497-501(1998).
//
RX   PubMed=10022529; DOI=10.1089/10430349950019174;
RA   Sumitomo M., Tachibana M., Ozu C., Asakura H., Murai M., Hayakawa M.,
RA   Nakamura H., Takayanagi A., Shimizu N.;
RT   "Induction of apoptosis of cytokine-producing bladder cancer cells by
RT   adenovirus-mediated IkappaBalpha overexpression.";
RL   Hum. Gene Ther. 10:37-47(1999).
//
RX   PubMed=10496353; DOI=10.1038/sj.bjc.6690688;
RA   Sumitomo M., Tachibana M., Murai M., Hayakawa M., Nakamura H.,
RA   Takayanagi A., Shimizu N.;
RT   "Overexpression of IL-1ra gene up-regulates interleukin-1beta
RT   converting enzyme (ICE) gene expression: possible mechanism underlying
RT   IL-1beta-resistance of cancer cells.";
RL   Br. J. Cancer 81:277-286(1999).
//
RX   PubMed=19802009; DOI=10.1038/onc.2009.315;
RA   Askham J.M., Platt F.M., Chambers P.A., Snowden H., Taylor C.F.,
RA   Knowles M.A.;
RT   "AKT1 mutations in bladder cancer: identification of a novel oncogenic
RT   mutation that can co-operate with E17K.";
RL   Oncogene 29:150-155(2010).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057;
RA   Hurst C.D., Platt F.M., Knowles M.A.;
RT   "Comprehensive mutation analysis of the TERT promoter in bladder
RT   cancer and detection of mutations in voided urine.";
RL   Eur. Urol. 65:367-369(2014).
//
RX   PubMed=24367658; DOI=10.1371/journal.pone.0084411;
RA   Ross R.L., Burns J.E., Taylor C.F., Mellor P., Anderson D.H.,
RA   Knowles M.A.;
RT   "Identification of mutations in distinct regions of p85 alpha in
RT   urothelial cancer.";
RL   PLoS ONE 8:E84411-E84411(2013).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29732388; DOI=10.3233/BLC-180167;
RA   Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.;
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023;
RA   Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III,
RA   Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K.,
RA   Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
RA   Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A.,
RA   Sellers W.R., Gygi S.P.;
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//