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Cellosaurus KY821 (CVCL_1346)

[Text version]

Cell line name KY821
Synonyms KY-821
Accession CVCL_1346
Resource Identification Initiative To cite this cell line use: KY821 (RRID:CVCL_1346)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~2 days (lot 11022006) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Meninges.
Sequence variations Heterozygous for NRAS p.Gln61His (c.183A>C) (CCLE; Cosmic-CLP).
Homozygous for TP53 p.Arg175His (c.524G>A) (ClinVar=VCV000012374) (PubMed=1571549; CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North76.02
East Asian, South23.98
South Asian0
European, North0
European, South0
Disease Acute myelomonocytic leukemia (NCIt: C7463)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_Z940 (KY-ADR2)CVCL_W293 (KY-MTX)CVCL_W294 (KY-Ra)
CVCL_5A05 (KY-Rb)CVCL_W295 (KY-VCR)CVCL_2806 (KY821A3)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO10,12
D5S81810,13
D7S82012
D13S3179,12
D16S53910,12
TH019
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Publications

CLPUB00069
Kishi K., Hanano M., Hirosawa H., Koike T., Sakai C., Aoyagi Y., Sanada M., Moiyama Y., Shibata A.
Characterization of a new human granulo-monocytic leukemic cell line.
Acta Haematol. Jpn. 46:122-122(1983)

PubMed=1560671; DOI=10.1016/0145-2126(92)90059-G
Saito H., Kishi K., Narita M., Furukawa T., Nagura E., Maekawa T., Abe T., Shibata A.
A new myeloblastic leukemia cell line with double minute chromosomes Induction of methotrexate resistance and dihydrofolate reductase gene amplification.
Leuk. Res. 16:217-226(1992)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H
Fukuda T., Kakihara T., Kamishima T., Ohnishi Y., Naito M., Kishi K., Shibata A.
Different effects of various hematopoietic growth factors on myelomonocytic cell line (KY-821) and its drug-resistant sublines.
Leuk. Res. 17:325-332(1993)

PubMed=9747033; DOI=10.1007/s100380050067
Ariyama Y., Sakabe T., Shinomiya T., Mori T., Fukuda Y., Inazawa J.
Identification of amplified DNA sequences on double minute chromosomes in a leukemic cell line KY821 by means of spectral karyotyping and comparative genomic hybridization.
J. Hum. Genet. 43:187-190(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21552520; DOI=10.1371/journal.pone.0019169
Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S., Tucker M., Kornhauser J., Ren J., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.
Survey of activated FLT3 signaling in leukemia.
PLoS ONE 6:E19169-E19169(2011)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB0105
Cell line databases/resources CCLE; KY821_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00553
Cosmic-CLP; 907300
DepMap; ACH-002262
LINCS_LDP; LCL-1004
Biological sample resources BioSample; SAMN03470792
Chemistry resources ChEMBL-Cells; CHEMBL3308834
ChEMBL-Targets; CHEMBL2366190
GDSC; 907300
PharmacoDB; KY821_797_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827265
GEO; GSM1670013
Other Wikidata; Q54900774
Polymorphism and mutation databases Cosmic; 907300
Cosmic; 975264
Cosmic; 2089651
Cosmic; 2131567
IARC_TP53; 2196
IARC_TP53; 21447
Entry history
Entry creation04-Apr-2012
Last entry updated02-Jul-2020
Version number28