Cellosaurus KY821 (CVCL_1346)

Cell line name KY821
Synonyms KY-821
Accession CVCL_1346
Resource Identification Initiative To cite this cell line use: KY821 (RRID:CVCL_1346)
Comments Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Disease Acute myelomonocytic leukemia (NCIt: C7463)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_Z940 (KY-ADR2)CVCL_W293 (KY-MTX)CVCL_W294 (KY-Ra)
CVCL_5A05 (KY-Rb)CVCL_W295 (KY-VCR)CVCL_2806 (KY821A3)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO10,12
D13S3179,12
D16S53910,12
D5S81810,13
D7S82012
TH019
TPOX11
vWA17,18
Publications

CLPUB00069
Kishi K., Hanano M., Hirosawa H., Koike T., Sakai C., Aoyagi Y., Sanada M., Moiyama Y., Shibata A.
Characterization of a new human granulo-monocytic leukemic cell line.
Acta Haematol. Jpn. 46:122-122(1983)

PubMed=1560671; DOI=10.1016/0145-2126(92)90059-G
Saito H., Kishi K., Narita M., Furukawa T., Nagura E., Maekawa T., Abe T., Shibata A.
A new myeloblastic leukemia cell line with double minute chromosomes Induction of methotrexate resistance and dihydrofolate reductase gene amplification.
Leuk. Res. 16:217-226(1992)

PubMed=8387619; DOI=10.1016/0145-2126(93)90019-H
Fukuda T., Kakihara T., Kamishima T., Ohnishi Y., Naito M., Kishi K., Shibata A.
Different effects of various hematopoietic growth factors on myelomonocytic cell line (KY-821) and its drug-resistant sublines.
Leuk. Res. 17:325-332(1993)

PubMed=9747033; DOI=10.1007/s100380050067
Ariyama Y., Sakabe T., Shinomiya T., Mori T., Fukuda Y., Inazawa J.
Identification of amplified DNA sequences on double minute chromosomes in a leukemic cell line KY821 by means of spectral karyotyping and comparative genomic hybridization.
J. Hum. Genet. 43:187-190(1998)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0105
Cell line databases/resources Cosmic-CLP; 907300
GDSC; 907300
LINCS_LDP; LCL-1004
Biological sample resources BioSample; SAMN03470792
Chemistry resources ChEMBL-Cells; CHEMBL3308834
ChEMBL-Targets; CHEMBL2366190
Gene expression databases GEO; GSM827265
GEO; GSM1670013
Polymorphism and mutation databases Cosmic; 907300
Cosmic; 975264
Cosmic; 2089651
Cosmic; 2131567