Cellosaurus KYSE-150 (CVCL_1348)

Cell line name KYSE-150
Synonyms KYSE 150; KYSE150; KY150
Accession CVCL_1348
Resource Identification Initiative To cite this cell line use: KYSE-150 (RRID:CVCL_1348)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 13.7 hours (PubMed=1728357); 23 hours (PubMed=25984343); <25 hours, less when serum amount is increased (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Esophageal squamous cell carcinoma (NCIt: C4024)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12,13
D13S3178,11
D16S5399,11
D18S5114
D21S1130,31
D3S135815,16
D5S81812,13
D7S82010,11
D8S117910,15
FGA21,24
Penta D10
Penta E12,18
TH017,9
TPOX8
vWA16,17
Publications

PubMed=1728357; DOI=10.1002/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C
Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.
Characterization of 21 newly established esophageal cancer cell lines.
Cancer 69:277-284(1992)

PubMed=7913084; DOI=10.1002/ijc.2910580224
Kanda Y., Nishiyama Y., Shimada Y., Imamura M., Nomura H., Hiai H., Fukumoto M.
Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.
Int. J. Cancer 58:291-297(1994)

PubMed=9033652; DOI=10.1002/(SICI)1097-0215(19970207)70:4<437::AID-IJC11>3.0.CO;2-C
Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.
Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.
Int. J. Cancer 70:437-442(1997)

PubMed=11092977; DOI=10.1111/j.1349-7006.2000.tb00895.x
Pimkhaokham A., Shimada Y., Fukuda Y., Kurihara N., Imoto I., Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.
Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.
Jpn. J. Cancer Res. 91:1126-1133(2000)

PubMed=15172977; DOI=10.1158/0008-5472.CAN-04-0172
Sonoda I., Imoto I., Inoue J., Shibata T., Shimada Y., Chin K., Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
Cancer Res. 64:3741-3747(2004)

PubMed=16045545; DOI=10.1111/j.0959-9673.2005.00431.x
Ban S., Michikawa Y., Ishikawa K.-I., Sagara M., Watanabe K., Shimada Y., Inazawa J., Imai T.
Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.
Int. J. Exp. Pathol. 86:231-240(2005)

PubMed=16832412; DOI=10.1038/sj.bjc.6603255
Tsunoda S., Okumura T., Ito T., Mori Y., Soma T., Watanabe G., Kaganoi J.-I., Itami A., Sakai Y., Shimada Y.
Significance of nerve growth factor overexpression and its autocrine loop in oesophageal squamous cell carcinoma.
Br. J. Cancer 95:322-330(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-375
JCRB; JCRB1095 - Discontinued
Cell line databases/resources CCLE; KYSE150_OESOPHAGUS
CGH-DB; 278-1
CGH-DB; 9227-4
Cosmic-CLP; 907317
GDSC; 907317
LINCS_HMS; 50025
LINCS_LDP; LCL-1548
Ontologies BTO; BTO:0002427
CLO; CLO_0007129
EFO; EFO_0006627
Biological sample resources BioSample; SAMN03471047
Chemistry resources ChEMBL-Cells; CHEMBL3307840
ChEMBL-Targets; CHEMBL613998
Gene expression databases GEO; GSM718289
GEO; GSM827545
GEO; GSM887248
GEO; GSM888323
GEO; GSM1670017
Polymorphism and mutation databases Cosmic; 907317
Cosmic; 918525
Cosmic; 929523
Cosmic; 1123338
Cosmic; 1581073
Cosmic; 1876252
Cosmic; 2267699
Cosmic; 2395002