ID   KYSE-520
AC   CVCL_1355
SY   KYSE 520; KYSE520; Kyse520; KYSE0520
DR   CLO; CLO_0007136
DR   EFO; EFO_0006632
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 922
DR   BioSample; SAMN03471053
DR   BioSample; SAMN10987932
DR   cancercelllines; CVCL_1355
DR   Cell_Model_Passport; SIDM01025
DR   CGH-DB; 289-1
DR   CGH-DB; 9238-4
DR   ChEMBL-Cells; CHEMBL3307804
DR   ChEMBL-Targets; CHEMBL612701
DR   Cosmic; 753575
DR   Cosmic; 918536
DR   Cosmic; 929528
DR   Cosmic; 1123344
DR   Cosmic; 2009521
DR   Cosmic; 2698445
DR   Cosmic-CLP; 753575
DR   DepMap; ACH-000637
DR   DSMZ; ACC-371
DR   DSMZCellDive; ACC-371
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 753575
DR   GEO; GSM590307
DR   GEO; GSM827538
DR   GEO; GSM887255
DR   GEO; GSM888330
DR   GEO; GSM1670025
DR   IARC_TP53; 7693
DR   JCRB; JCRB1439
DR   LiGeA; CCLE_661
DR   LINCS_LDP; LCL-1556
DR   PharmacoDB; KYSE520_811_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1355
DR   PubChem_Cell_line; CVCL_1355
DR   Wikidata; Q54900834
RX   PubMed=1728357;
RX   PubMed=7913084;
RX   PubMed=8575860;
RX   PubMed=9033652;
RX   PubMed=11092977;
RX   PubMed=11520067;
RX   PubMed=12963126;
RX   PubMed=15172977;
RX   PubMed=16045545;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=31068700;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 30.2 hours (PubMed=1728357); ~30 hours (DSMZ=ACC-371).
CC   HLA typing: A*24:20,24:20; B*54:01,54:01; C*01:02,01:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.376-2A>T; ClinVar=VCV000458540; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=8575860).
CC   Omics: CRISPR phenotypic screen.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=1.52%; Native American=1.16%; East Asian, North=82.25%; East Asian, South=12.37%; South Asian=0%; European, North=0%; European, South=2.7% (PubMed=30894373).
CC   Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
ST   Source(s): Cosmic-CLP; DSMZ; JCRB; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 10
ST   D18S51: 14
ST   D19S433: 14,16
ST   D21S11: 29
ST   D2S1338: 19
ST   D3S1358: 16
ST   D5S818: 9
ST   D7S820: 11
ST   D8S1179: 14,16
ST   FGA: 22
ST   Penta D: 12
ST   Penta E: 15
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 15,17
DI   NCIt; C4024; Esophageal squamous cell carcinoma
DI   ORDO; Orphanet_99977; Squamous cell carcinoma of the esophagus
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 43
//
RX   PubMed=1728357; DOI=10.1002/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C;
RA   Shimada Y., Imamura M., Wagata T., Yamaguchi N., Tobe T.;
RT   "Characterization of 21 newly established esophageal cancer cell
RT   lines.";
RL   Cancer 69:277-284(1992).
//
RX   PubMed=7913084; DOI=10.1002/ijc.2910580224;
RA   Kanda Y., Nishiyama Y., Shimada Y., Imamura M., Nomura H., Hiai H.,
RA   Fukumoto M.;
RT   "Analysis of gene amplification and overexpression in human
RT   esophageal-carcinoma cell lines.";
RL   Int. J. Cancer 58:291-297(1994).
//
RX   PubMed=8575860; DOI=10.1002/(SICI)1097-0215(19960126)65:3<372::AID-IJC16>3.0.CO;2-C;
RA   Tanaka H., Shibagaki I., Shimada Y., Wagata T., Imamura M.,
RA   Ishizaki K.;
RT   "Characterization of p53 gene mutations in esophageal squamous cell
RT   carcinoma cell lines: increased frequency and different spectrum of
RT   mutations from primary tumors.";
RL   Int. J. Cancer 65:372-376(1996).
//
RX   PubMed=9033652; DOI=10.1002/(SICI)1097-0215(19970207)70:4<437::AID-IJC11>3.0.CO;2-C;
RA   Tanaka H., Shimada Y., Imamura M., Shibagaki I., Ishizaki K.;
RT   "Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b)
RT   genes in 30 esophageal squamous-cell-carcinoma cell lines.";
RL   Int. J. Cancer 70:437-442(1997).
//
RX   PubMed=11092977; DOI=10.1111/j.1349-7006.2000.tb00895.x;
RA   Pimkhaokham A., Shimada Y., Fukuda Y., Kurihara N., Imoto I.,
RA   Yang Z.-Q., Imamura M., Nakamura Y., Amagasa T., Inazawa J.;
RT   "Nonrandom chromosomal imbalances in esophageal squamous cell
RT   carcinoma cell lines: possible involvement of the ATF3 and CENPF genes
RT   in the 1q32 amplicon.";
RL   Jpn. J. Cancer Res. 91:1126-1133(2000).
//
RX   PubMed=11520067; DOI=10.1006/bbrc.2001.5400;
RA   Kan T., Shimada Y., Sato F., Maeda M., Kawabe A., Kaganoi J.-i.,
RA   Itami A., Yamasaki S., Imamura M.;
RT   "Gene expression profiling in human esophageal cancers using cDNA
RT   microarray.";
RL   Biochem. Biophys. Res. Commun. 286:792-801(2001).
//
RX   PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6;
RA   Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E.,
RA   Sidransky D.;
RT   "PUMA in head and neck cancer.";
RL   Cancer Lett. 199:75-81(2003).
//
RX   PubMed=15172977; DOI=10.1158/0008-5472.CAN-04-0172;
RA   Sonoda I., Imoto I., Inoue J., Shibata T., Shimada Y., Chin K.,
RA   Imamura M., Amagasa T., Gray J.W., Hirohashi S., Inazawa J.;
RT   "Frequent silencing of low density lipoprotein receptor-related
RT   protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in
RT   esophageal squamous cell carcinoma.";
RL   Cancer Res. 64:3741-3747(2004).
//
RX   PubMed=16045545; DOI=10.1111/j.0959-9673.2005.00431.x;
RA   Ban S., Michikawa Y., Ishikawa K.-i., Sagara M., Watanabe K.,
RA   Shimada Y., Inazawa J., Imai T.;
RT   "Radiation sensitivities of 31 human oesophageal squamous cell
RT   carcinoma cell lines.";
RL   Int. J. Exp. Pathol. 86:231-240(2005).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M.,
RA   Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R.,
RA   Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P.,
RA   van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L.,
RA   Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.;
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//