Cellosaurus L-428 (CVCL_1361)

Cell line name L-428
Synonyms L 428; L428
Accession CVCL_1361
Resource Identification Initiative To cite this cell line use: L-428 (RRID:CVCL_1361)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~35 hours (DSMZ).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Cell surface proteome.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using RNAseq.
Derived from sampling site: Pleural effusion.
Disease Hodgkin lymphoma (NCIt: C9357)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_X206 (L-428 KS)CVCL_X207 (L-428 KSA)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO10,13
D13S31714
D16S53911,12
D5S81811,12
D7S82011
TH017,9.3
TPOX8,9
vWA15
Publications

PubMed=7216541; DOI=10.1002/ijc.2910260605
Schaadt M., Diehl V., Stein H., Fonatsch C., Kirchner H.H.
Two neoplastic cell lines with unique features derived from Hodgkin's disease.
Int. J. Cancer 26:723-731(1980)

PubMed=7276066; DOI=10.1007/BF00405072
Diehl V., Kirchner H.H., Schaadt M., Fonatsch C., Stein H., Gerdes J., Boie C.
Hodgkin's disease: establishment and characterization of four in vitro cell lies.
J. Cancer Res. Clin. Oncol. 101:111-124(1981)

PubMed=6303739; DOI=10.1055/s-2008-1069671
Kirchner H.H., Burrichter H., Stein H., Fonatsch C., Schaadt M., Ziegler A., Heit W., Diehl V.
Properties of Hodgkin cell lines. Possible significance for pathophysiology and clinical medicine.
Dtsch. Med. Wochenschr. 108:936-944(1983)

PubMed=6305805
Diehl V., Burrichter H., Schaadt M., Kirchner H.H., Fonatsch C., Stein H., Gerdes J., Heit W., Ziegler A.
Hodgkin's disease cell lines: characteristics and biological activities.
Haematol. Blood Transfus. 28:411-417(1983)

PubMed=3713248; DOI=10.1016/0145-2126(86)90084-6
Drexler H.G., Gaedicke G., Lok M.-S., Diehl V., Minowada J.
Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles.
Leuk. Res. 10:487-500(1986)

PubMed=2898211
Newcom S.R., Kadin M.E., Ansari A.A.
Production of transforming growth factor-beta activity by Ki-1 positive lymphoma cells and analysis of its role in the regulation of Ki-1 positive lymphoma growth.
Am. J. Pathol. 131:569-577(1988)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-197
Cell line databases/resources CLDB; cl3081
CCLE; L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 907322
GDSC; 907322
IGRhCellID; L428
LINCS_LDP; LCL-2011
Lonza; 924
Ontologies BTO; BTO:0000406
CLO; CLO_0007189
EFO; EFO_0002225
Biological sample resources BioSample; SAMN03473371
Chemistry resources ChEMBL-Cells; CHEMBL3308873
ChEMBL-Targets; CHEMBL2366233
Gene expression databases GEO; GSM499721
GEO; GSM499729
GEO; GSM552447
GEO; GSM637988
GEO; GSM887260
GEO; GSM888335
GEO; GSM1670029
Polymorphism and mutation databases Cosmic; 850218
Cosmic; 907322
Cosmic; 988703
Cosmic; 1013907
Cosmic; 1086358
Cosmic; 1278830
Cosmic; 1289698
Cosmic; 1432036
Cosmic; 1714161
Cosmic; 2276326
Cosmic; 2361389
Cosmic; 2464304
Proteomic databases PRIDE; PXD000589