Cellosaurus L-540 (CVCL_1362)

Cell line name L-540
Synonyms L 540; L540
Accession CVCL_1362
Resource Identification Initiative To cite this cell line use: L-540 (RRID:CVCL_1362)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~70 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Cell surface proteome.
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using RNAseq.
Derived from sampling site: Bone marrow.
Disease Hodgkin lymphoma (NCIt: C9357)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M700 ! L-538
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO11,13
D13S3179
D16S53911,13
D5S81811,13
D7S82011,12
TH017,9
TPOX9,10
vWA17,18
Publications

PubMed=7276066; DOI=10.1007/BF00405072
Diehl V., Kirchner H.H., Schaadt M., Fonatsch C., Stein H., Gerdes J., Boie C.
Hodgkin's disease: establishment and characterization of four in vitro cell lies.
J. Cancer Res. Clin. Oncol. 101:111-124(1981)

PubMed=6303739; DOI=10.1055/s-2008-1069671
Kirchner H.H., Burrichter H., Stein H., Fonatsch C., Schaadt M., Ziegler A., Heit W., Diehl V.
Properties of Hodgkin cell lines. Possible significance for pathophysiology and clinical medicine.
Dtsch. Med. Wochenschr. 108:936-944(1983)

PubMed=6305805
Diehl V., Burrichter H., Schaadt M., Kirchner H.H., Fonatsch C., Stein H., Gerdes J., Heit W., Ziegler A.
Hodgkin's disease cell lines: characteristics and biological activities.
Haematol. Blood Transfus. 28:411-417(1983)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8
Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C., Lagercrantz S., Enblad G.
Molecular cytogenetic characterization of four commonly used cell lines derived from Hodgkin lymphoma.
Cancer Genet. Cytogenet. 141:43-48(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-72
Cell line databases/resources CLDB; cl455
CCLE; L540_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 907323
GDSC; 907323
LINCS_LDP; LCL-2012
Lonza; 72
Ontologies BTO; BTO:0005176
CLO; CLO_0007201
Biological sample resources BioSample; SAMN03473399
Chemistry resources ChEMBL-Cells; CHEMBL3308531
ChEMBL-Targets; CHEMBL2366153
Gene expression databases GEO; GSM335392
GEO; GSM499725
GEO; GSM499726
GEO; GSM552448
GEO; GSM646532
GEO; GSM646535
GEO; GSM887261
GEO; GSM888336
GEO; GSM1670030
Polymorphism and mutation databases Cosmic; 907323
Cosmic; 988705
Cosmic; 1013911
Cosmic; 1086359
Cosmic; 1432039
Cosmic; 2276327
Cosmic; 2464307
Proteomic databases PRIDE; PXD000589