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Cellosaurus LA-N-6 (CVCL_1363)

[Text version]

Cell line name LA-N-6
Synonyms LAN-6; LAN6; LA-N-6(OAN)
Accession CVCL_1363
Resource Identification Initiative To cite this cell line use: LA-N-6 (RRID:CVCL_1363)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Characteristics: Neuroblastic type (N-type) (PubMed=15720811).
Doubling time: ~1 week (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Deep tyrosine phosphoproteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for ALK p.Asp1091Asn (c.3271G>A) (PubMed=18724359; CCLE; Cosmic-CLP).
Heterozygous for KRAS p.Gly12Cys (c.34G>T) (CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Pro152Leu (c.455C>T) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American23.6
East Asian, North3.12
East Asian, South0
South Asian0
European, North42.61
European, South28.2
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): COG; Cosmic-CLP; DSMZ


Run an STR similarity search on this cell line
Web pages http://www.cogcell.org/dl/NB_Data_Sheets/LA-N-6_Cell_Line_Data_Sheet_COGcell_org.pdf

PubMed=8242562; DOI=10.1002/1097-0142(19931201)72:11<3346::AID-CNCR2820721134>3.0.CO;2-E
Wada R.K., Seeger R.C., Brodeur G.M., Einhorn P.A., Rayner S.A., Tomayko M.M., Reynolds C.P.
Human neuroblastoma cell lines that express N-myc without gene amplification.
Cancer 72:3346-3354(1993)

Thiele C.J.
(In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999)

Keshelava N., Zuo J.J., Chen P., Waidyaratne S.N., Luna M.C., Gomer C.J., Triche T.J., Reynolds C.P.
Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines.
Cancer Res. 61:6185-6193(2001)

PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809
Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R., Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B., Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G., Gabbert H.E., Poremba C.
Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3.
Cancer Res. 64:3395-3405(2004)

PubMed=15720811; DOI=10.1593/neo.04310
Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F., Biedler J.L., Cheung N.-K.V., Ross R.A.
Characteristics of stem cells from human neuroblastoma cell lines and in tumors.
Neoplasia 6:838-845(2004)

PubMed=16822308; DOI=10.1186/1471-2407-6-177
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177-177(2006)

PubMed=18724359; DOI=10.1038/nature07261
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23202128; DOI=10.1038/ng.2493
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Farooqi A.S., Dagg R.A., Choi L.M.R., Shay J.W., Reynolds C.P., Lau L.M.S.
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=25884760; DOI=10.1371/journal.pcbi.1004130
Palacios-Moreno J., Foltz L., Guo A., Stokes M.P., Kuehn E.D., George L., Comb M., Grimes M.L.
Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.
PLoS Comput. Biol. 11:E1004130-E1004130(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections DSMZ; ACC-674
Cell line databases/resources CCLE; LAN6_AUTONOMIC_GANGLIA
Cell_Model_Passport; SIDM00330
Cosmic-CLP; 949170
DepMap; ACH-001355
Biological sample resources BioSample; SAMN03473429
Chemistry resources ChEMBL-Cells; CHEMBL3308206
ChEMBL-Targets; CHEMBL2366123
GDSC; 949170
PharmacoDB; LAN6_819_2019
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670032
GEO; GSM2371240
GEO; GSM2394373
Other Wikidata; Q54901879
Polymorphism and mutation databases Cosmic; 697283
Cosmic; 717430
Cosmic; 848929
Cosmic; 930067
Cosmic; 949170
Cosmic; 1019942
Cosmic; 1109105
Cosmic; 1109366
Cosmic; 1161993
Cosmic; 1167408
Cosmic; 1526630
Cosmic; 1890102
Cosmic; 2301577
Cosmic; 2393637
IARC_TP53; 23822
IARC_TP53; 27562
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-20
Version number28