ID   LB1047-RCC
AC   CVCL_1364
SY   LB1047RCC; LB1047
DR   CLO; CLO_0009979
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 924
DR   cancercelllines; CVCL_1364
DR   Cell_Model_Passport; SIDM00187
DR   ChEMBL-Cells; CHEMBL3308329
DR   ChEMBL-Targets; CHEMBL2366136
DR   Cosmic; 753577
DR   Cosmic-CLP; 753577
DR   DepMap; ACH-002150
DR   EGA; EGAS00001000978
DR   GDSC; 753577
DR   GEO; GSM1670033
DR   IARC_TP53; 21460
DR   LINCS_LDP; LCL-1765
DR   PharmacoDB; LB1047RCC_820_2019
DR   PRIDE; PXD030304
DR   PubChem_Cell_line; CVCL_1364
DR   Wikidata; Q54902027
RX   PubMed=10074909;
RX   PubMed=11369790;
RX   PubMed=18698046;
RX   PubMed=20164919;
RX   PubMed=27397505;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   From: Ludwig Institute for Cancer Research, Brussels Branch; Brussels; Belgium.
CC   Population: Caucasian.
CC   HLA typing: A*02:01,24:02:101; B*35:01,51; C*04:01,16:02 (PubMed=11369790).
CC   Microsatellite instability: Instable (MSI-high) (Sanger).
CC   Omics: CRISPR phenotypic screen.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0.9%; Native American=0%; East Asian, North=0.45%; East Asian, South=0%; South Asian=20.18%; European, North=20.14%; European, South=58.33% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): Cosmic-CLP
ST   Amelogenin: X
ST   CSF1PO: 11,13
ST   D13S317: 11,12
ST   D16S539: 11
ST   D5S818: 12,13
ST   D7S820: 9
ST   TH01: 7
ST   TPOX: 8,10
ST   vWA: 15,16
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_E908 ! LB1047-EBV
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 34
//
RX   PubMed=10074909; DOI=10.1002/(SICI)1097-0215(19990315)80:6<799::AID-IJC1>3.0.CO;2-U;
RA   Dumas F., Gala J.-L., Berteau P., Brasseur F., Eschwege P., Paradis V.,
RA   Lacour B., Philippe M., Loric S.;
RT   "Molecular expression of PSMA mRNA and protein in primary renal
RT   tumors.";
RL   Int. J. Cancer 80:799-803(1999).
//
RX   PubMed=11369790; DOI=10.1084/jem.193.10.1189;
RA   Probst-Kepper M., Stroobant V., Kridel R., Gaugler B., Landry C.,
RA   Brasseur F., Cosyns J.-P., Weynand B., Boon T., van den Eynde B.J.;
RT   "An alternative open reading frame of the human macrophage
RT   colony-stimulating factor gene is independently translated and codes
RT   for an antigenic peptide of 14 amino acids recognized by
RT   tumor-infiltrating CD8 T lymphocytes.";
RL   J. Exp. Med. 193:1189-1198(2001).
//
RX   PubMed=18698046; DOI=10.1158/1078-0432.CCR-08-0028;
RA   Tykodi S.S., Fujii N., Vigneron N., Lu S.M., Mito J.K., Miranda M.X.,
RA   Chou J., Voong L.N., Thompson J.A., Sandmaier B.M., Cresswell P.,
RA   Van den Eynde B.J., Riddell S.R., Warren E.H.;
RT   "C19orf48 encodes a minor histocompatibility antigen recognized by
RT   CD8+ cytotoxic T cells from renal cell carcinoma patients.";
RL   Clin. Cancer Res. 14:5260-5269(2008).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28489074; DOI=10.1038/ncomms15165;
RA   Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y.-Y.,
RA   Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C.,
RA   Hsieh J.J.-D., Hakimi A.A.;
RT   "Analysis of renal cancer cell lines from two major resources enables
RT   genomics-guided cell line selection.";
RL   Nat. Commun. 8:15165.1-15165.10(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M.,
RA   Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R.,
RA   Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P.,
RA   van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L.,
RA   Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.;
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//