Cell line name | LC-2/ad | ||||||||||||||||||
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Synonyms | LC-2-Ad; LC-2-ad; LC-2 ad; LC2/Ad; LC2/AD | ||||||||||||||||||
Accession | CVCL_1373 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: LC-2/ad (RRID:CVCL_1373) | ||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Population: Japanese. Doubling time: 58 hours, at 32th passage (PubMed=8291444). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. Caution: Indicated to have a EGFR p.Leu858Arg (c.2573T>G) (ClinVar=VCV000016609) mutation according to PubMed=16105816) but this is in contradiction of results of exome sequencing in CCLE and Cosmic-CLP. | ||||||||||||||||||
Sequence variations | Gene fusion; CCDC6-RET (RET/PTC1) (PubMed=23578175).Homozygous for TP53 p.Ser241Cys (c.722C>G) (ClinVar=VCV000177791) (CCLE; Cosmic-CLP). | ||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Lung adenocarcinoma (NCIt: C3512) Derived from metastatic site: Pleural effusion. | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Sex of cell | Female | ||||||||||||||||||
Age at sampling | 51Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): Cosmic-CLP; ECACC; RCB Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | PubMed=8291444; DOI=10.1111/j.1440-1827.1993.tb03232.x PubMed=8348978; DOI=10.1016/0014-5793(93)80946-R PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331 PubMed=20164919; DOI=10.1038/nature08768 PubMed=22313637; DOI=10.4161/cbt.19238 PubMed=23154560; DOI=10.1097/JTO.0b013e3182721ed1 PubMed=23578175; DOI=10.1111/cas.12175 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections | ECACC; 94072247
RCB; RCB0440 | ||||||||||||||||||
Cell line databases/resources | CCLE; LC2AD_LUNG
Cell_Model_Passport; SIDM00297 Cosmic-CLP; 907786 DepMap; ACH-002157 LINCS_LDP; LCL-1667 | ||||||||||||||||||
Ontologies | CLO; CLO_0050073
EFO; EFO_0003140 | ||||||||||||||||||
Biological sample resources | BioSample; SAMN03472314 | ||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3308545
ChEMBL-Targets; CHEMBL2366260 GDSC; 907786 PharmacoDB; LC2ad_831_2019 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-3610
GEO; GSM1670043 | ||||||||||||||||||
Other | Wikidata; Q54902124 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 907786
Cosmic; 946052 Cosmic; 1154602 Cosmic; 1571726 Cosmic; 1656903 Cosmic; 1995480 IARC_TP53; 21470 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||
Version number | 26 |