Cellosaurus LC4-1 (CVCL_1374)

Cell line name LC4-1
Accession CVCL_1374
Resource Identification Initiative To cite this cell line use: LC4-1 (RRID:CVCL_1374)
Comments Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX
CSF1PO10,13
D13S3178,12
D16S5399,10
D5S81810,12
D7S8208,10
TH017,9
TPOX9,11
vWA17,19
Publications

PubMed=3115091; DOI=10.1002/ajh.2830260106
Yoshimura T., Mayumi M., Yorifuji T., Kim K.-M., Heike T., Miyanomae T., Shinomiya K., Mikawa H.
Establishment of a common acute lymphoblastic leukemia cell line (LC4-1) and effects of phorbol myristate acetate (PMA) on the surface antigen expression of the cell line.
Am. J. Hematol. 26:47-54(1987)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB0114
Cell line databases/resources Cosmic-CLP; 907787
GDSC; 907787
LINCS_LDP; LCL-1037
Ontologies BTO; BTO:0004945
Biological sample resources BioSample; SAMN03470796
Chemistry resources ChEMBL-Cells; CHEMBL3308835
ChEMBL-Targets; CHEMBL2366091
Gene expression databases GEO; GSM827293
GEO; GSM1670044
Polymorphism and mutation databases Cosmic; 907787
Cosmic; 996283
Cosmic; 998692
Cosmic; 1037719