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Cellosaurus LN-405 (CVCL_1378)

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Cell line name LN-405
Synonyms LN 405; LN405
Accession CVCL_1378
Resource Identification Initiative To cite this cell line use: LN-405 (RRID:CVCL_1378)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Arg282Trp (c.844C>T) (PubMed=10416987).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.81
Native American0
East Asian, North1.39
East Asian, South0
South Asian3.12
European, North55.54
European, South38.13
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=11416159; PubMed=22570425

Markers:
AmelogeninX
CSF1PO10,11
D3S135814
D5S81811,12
D7S8209,11
D8S117913
D13S3178
D16S53910
D18S5112,15
D21S1129,31.2
FGA22,24
Penta D8,11
Penta E17
TH018,9.3
TPOX8,11
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x
Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112
Grzmil M., Morin P. Jr., Lino M.M., Merlo A., Frank S., Wang Y., Moncayo G., Hemmings B.A.
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Cancer Res. 71:2392-2402(2011)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-189
Cell line databases/resources CLDB; cl3242
CCLE; LN405_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM00343
Cosmic-CLP; 910694
GDSC; 910694
LINCS_LDP; LCL-1395
Ontologies CLO; CLO_0007364
Biological sample resources BioSample; SAMN03473369
Chemistry resources ChEMBL-Cells; CHEMBL3308756
ChEMBL-Targets; CHEMBL1075491
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM326241
GEO; GSM1670050
Other Wikidata; Q54902781
Polymorphism and mutation databases Cosmic; 687578
Cosmic; 849868
Cosmic; 910694
Cosmic; 1746949
Cosmic; 2302332
Cosmic; 2367536
Cosmic; 2580914
IARC_TP53; 21474
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number22