Cellosaurus LN-405 (CVCL_1378)

Cell line name LN-405
Synonyms LN 405; LN405
Accession CVCL_1378
Resource Identification Initiative To cite this cell line use: LN-405 (RRID:CVCL_1378)
Comments Doubling time: ~60 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=11416159; PubMed=22570425

Markers:
AmelogeninX
CSF1PO10,11
D13S3178
D16S53910
D18S5112,15
D21S1129,31.2
D3S135814
D5S81811,12
D7S8209,11
D8S117913
FGA22,24
Penta D8,11
Penta E17
TH018,9.3
TPOX8,11
vWA15,16
Publications

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x
Ishii N., Maier D., Merlo A., Tada M., Sawamura Y., Diserens A.-C., Van Meir E.G.
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112
Grzmil M., Morin P. Jr., Lino M.M., Merlo A., Frank S., Wang Y., Moncayo G., Hemmings B.A.
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Cancer Res. 71:2392-2402(2011)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-189
Cell line databases/resources CLDB; cl3242
Cosmic-CLP; 910694
GDSC; 910694
LINCS_LDP; LCL-1395
Ontologies CLO; CLO_0007364
Biological sample resources BioSample; SAMN03473369
Chemistry resources ChEMBL-Cells; CHEMBL3308756
ChEMBL-Targets; CHEMBL1075491
Gene expression databases GEO; GSM326241
GEO; GSM1670050
Polymorphism and mutation databases Cosmic; 687578
Cosmic; 849868
Cosmic; 910694
Cosmic; 1746949
Cosmic; 2302332
Cosmic; 2367536